Basic Information

Symbol
PTPA
RNA class
mRNA
Alias
Protein Phosphatase 2 Phosphatase Activator Phosphotyrosyl Phosphatase Activator PPP2R4 PR53 Serine/Threonine-Protein Phosphatase 2A Regulatory Subunit B' Protein Phosphatase 2A Activator, Regulatory Subunit 4 Protein Phosphatase 2A, Regulatory Subunit B' (PR 53) Serine/Threonine-Protein Phosphatase 2A Activator Protein Phosphatase 2 Regulatory Subunit 4 PP2A Phosphatase Activator Serine/Threonine-Protein Phosphatase 2A Regulatory Subunit 4 Protein Phosphatase 2A Regulatory Subunit 4 PP2A, Subunit B', PR53 Isoform EC 5.2.1.8 PARK25 PP2A
Location (GRCh38)
9:129110550-129148946
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_178000.3
Sequence length
2640.0 nt
GC content
0.5917

Transcripts

ID Sequence Length GC content
NM_001193397.2 NCBI
GUGUGGGAGGCUCAGGAGGGCGAGAGUCAUGACACGGAGGAACUGGAGG… 2527 nt 0.5888
NM_001271832.2 NCBI
ACCGACAUGGCGGCCGUCUUCGCUGUGGUGACUUUAACUCUCGGUUUUC… 2553 nt 0.5942
NM_021131.5 NCBI
AUUGAGACCUGUGGAGGAGGAAGGAGGAGGUCACCGUCCAGCUGUCUCU… 2666 nt 0.5923
NM_178000.3 NCBI
ACCGACAUGGCGGCCGUCUUCGCUGUGGUGACUUUAACUCUCGGUUUUC… 2640 nt 0.5917
NM_178001.3 NCBI
ACCGACAUGGCGGCCGUCUUCGCUGUGGUGACUUUAACUCUCGGUUUUC… 2745 nt 0.5902
NM_178003.3 NCBI
ACCGACAUGGCGGCCGUCUUCGCUGUGGUGACUUUAACUCUCGGUUUUC… 2514 nt 0.5955
Summary

Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Forensic Context

A study in mice demonstrated that ionizing radiation (6 or 12 Gy X-ray) induced gastric injury, characterized by mucosal atrophy and altered cell morphology, and identified the PTPA as one of 17 commonly upregulated mRNAs in irradiated gastric tissues [Chen et al. DOI:10.1177/1559325819886766].