Basic Information

Symbol
PTPN14
RNA class
mRNA
Alias
Protein Tyrosine Phosphatase Non-Receptor Type 14 PTPD2 PEZ Tyrosine-Protein Phosphatase Non-Receptor Type 14 Protein-Tyrosine Phosphatase Pez EC 3.1.3.48 Cytoskeletal-Associated Protein Tyrosine Phosphatase EC 3.1.3 CATLPH PTP36
Location (GRCh38)
1:214348700-214552449
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_005401.5
Sequence length
13360.0 nt
GC content
0.4641

Transcripts

ID Sequence Length GC content
NM_005401.5 NCBI
CUUUCCAACUUUUUCUCGGCGGAGUGAGCGCAGCGGGCGCAGACUCGGG… 13360 nt 0.4641
Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. It appears to regulate lymphatic development in mammals, and a loss of function mutation has been found in a kindred with a lymphedema-choanal atresia. [provided by RefSeq, Sep 2010]

Forensic Context

No relevant information is available at the moment.