Basic Information

Symbol
PTPN6
RNA class
mRNA
Alias
Protein Tyrosine Phosphatase Non-Receptor Type 6 PTP-1C HCP SHP-1 HCPH SHP1 Tyrosine-Protein Phosphatase Non-Receptor Type 6 Hematopoietic Cell Protein-Tyrosine Phosphatase Protein-Tyrosine Phosphatase SHP-1 Protein-Tyrosine Phosphatase 1C EC 3.1.3.48 SH-PTP1 Hematopoietic Cell Phosphatase HPTP1C SHP-1L PTP1C
Location (GRCh38)
12:6946417-6961316
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002831.6
Sequence length
2161.0 nt
GC content
0.5868

Transcripts

ID Sequence Length GC content
NM_002831.6 NCBI
AGUGGAGUGGCAGCCCCAGAACUGGGACCACCGGGGGUGGUGAGGCGGC… 2161 nt 0.5868
NM_080548.5 NCBI
AUUGGCCUGGCAGGCAGGAUCGAGGAGGAAGUGGCUGAUUACUGAGCGG… 2159 nt 0.5859
NM_080549.4 NCBI
AGUGGAGUGGCAGCCCCAGAACUGGGACCACCGGGGGUGGUGAGGCGGC… 2304 nt 0.5920
Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008] CIViC Summary for PTPN6 Gene

Forensic Context

A study in human traumatic brain injury (TBI) patients identified the PTPN6 as one of the top five upregulated long noncoding RNAs in brain contusion tissues compared to adjacent tissues, with a log2(fold change) of 5.691601 [Zhang et al. DOI:10.097/WNR.0000000000001756].