Basic Information

Symbol
PTPRD
RNA class
mRNA
Alias
Protein Tyrosine Phosphatase Receptor Type D PTPD HPTP Receptor-Type Tyrosine-Protein Phosphatase Delta R-PTP-Delta EC 3.1.3.48 Protein Tyrosine Phosphatase, Receptor Type, Delta Polypeptide Rceptor-Type Tyrosine-Protein Phosphatase Delta Protein-Tyrosine Phosphatase Delta HPTPDELTA RPTPDELTA HPTPD
Location (GRCh38)
9:8314246-10613002
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Forensic psychiatry evaluation Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002839.4
Sequence length
10389.0 nt
GC content
0.4345

Transcripts

ID Sequence Length GC content
NM_001040712.2 NCBI
GCUCUGAAAGUGUUCCAGCUGAAAUUUCAGAUCGGACAGACUCGCUGCG… 8257 nt 0.4109
NM_001171025.2 NCBI
ACUCGCUGACUCUCUUCCACUUCCUCGCUCUGGACUGGGCUGGCCGCAC… 8479 nt 0.4207
NM_001377946.1 NCBI
ACUCGCUGACUCUCUUCCACUUCCUCGCUCUGGACUGGGCUGGCCGCAC… 8491 nt 0.4209
NM_001377947.1 NCBI
ACUCGCUGACUCUCUUCCACUUCCUCGCUCUGGACUGGGCUGGCCGCAC… 8727 nt 0.4296
NM_001377958.1 NCBI
ACUCGCUGACUCUCUUCCACUUCCUCGCUCUGGACUGGGCUGGCCGCAC… 9760 nt 0.4298
NM_001378058.1 NCBI
ACUCGCUGACUCUCUUCCACUUCCUCGCUCUGGACUGGGCUGGCCGCAC… 9715 nt 0.4297
NM_002839.4 NCBI
GAGUGCGAGCGAGACGAGGAGGGAGCGCCAGCGAGCGAGCGAGCGAGUG… 10389 nt 0.4345
NM_130391.4 NCBI
GUGAUGUUGAAAAGGCUGACAGAUAACUGAGAGAUGUUUUCAUCUCUAA… 8310 nt 0.4118
NM_130392.3 NCBI
GCUCUGAAAGUGUUCCAGCUGAAAUUUCAGAUCGGACAGACUCGCUGCG… 8269 nt 0.4108
NM_130393.3 NCBI
GCUCUGAAAGUGUUCCAGCUGAAAUUUCAGAUCGGACAGACUCGCUGCG… 8239 nt 0.4106
Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple alternatively spliced transcript variants of this gene have been reported. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jan 2010] CIViC Summary for PTPRD Gene

Forensic Context

A study in mice demonstrated that perinatal lead (Pb) exposure altered adult hippocampal gene expression, with the PTPRD identified as a top marker gene for the oligodendrocyte cluster 10 [Bakulski et al. DOI:10.1093/toxsci/kfaa069]. A review on single-cell transcriptomics in forensic medicine cited this finding, noting that genes like the PTPRD represent potential molecular links between Pb poisoning and psychiatric disorders, indicating its relevance for forensic molecular diagnosis and pathogenesis understanding [Yang et al. DOI:10.1007/s00414-022-02889-9].