Basic Information

Symbol
PTPRJ
RNA class
mRNA
Alias
Protein Tyrosine Phosphatase Receptor Type J DEP1 HPTPeta CD148 Receptor-Type Tyrosine-Protein Phosphatase Eta Protein-Tyrosine Phosphatase Eta Density-Enhanced Phosphatase 1 CD148 Antigen EC 3.1.3.48 HPTP Eta R-PTP-J Protein Tyrosine Phosphatase, Receptor Type, J Polypeptide Susceptibility To Colon Cancer 1, Mouse, Homolog Of Protein-Tyrosine Phosphatase Receptor Type J Human Density Enhanced Phosphatase-1 R-PTP-ETA R-PTP-Eta THC10 DEP-1 SCC1
Location (GRCh38)
11:47980425-48170839
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002843.4
Sequence length
7845.0 nt
GC content
0.4803

Transcripts

ID Sequence Length GC content
NM_001098503.2 NCBI
AGCCCCAGCCGCAUGACGCGCGGAGGAGGCAGCGGGAGCAGCCGCGGGA… 3179 nt 0.4942
NM_002843.4 NCBI
AGCCCCAGCCGCAUGACGCGCGGAGGAGGCAGCGGGAGCAGCCGCGGGA… 7845 nt 0.4803
Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Forensic Context

No relevant information is available at the moment.