Basic Information

Symbol
PTPRO
RNA class
mRNA
Alias
Protein Tyrosine Phosphatase Receptor Type O GLEPP1 PTP-U2 PTPU2 PTP-Oc NPHS6 Osteoclastic Transmembrane Protein-Tyrosine Phosphatase Receptor-Type Tyrosine-Protein Phosphatase O Glomerular Epithelial Protein 1 EC 3.1.3.48 PTPase U2 R-PTP-O Protein Tyrosine Phosphatase PTP-U2 Protein Tyrosine Phosphatase U2 Phosphotyrosine Phosphatase U2 PTP Phi PTPROT
Location (GRCh38)
12:15322257-15602175
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_030667.3
Sequence length
6128.0 nt
GC content
0.4413

Transcripts

ID Sequence Length GC content
NM_002848.4 NCBI
AGUCAUUAAAGAACAGCAGCGCCUGGCACGUUCUUGGAGGACCCCGGGC… 6044 nt 0.4423
NM_030667.3 NCBI
AGUCAUUAAAGAACAGCAGCGCCUGGCACGUUCUUGGAGGACCCCGGGC… 6128 nt 0.4413
NM_030668.3 NCBI
AGACUUCAGUGACUUUGCUGUGGGUGGAAGAGGGAGUAGCUGAUUUCUU… 3619 nt 0.4335
NM_030669.3 NCBI
AGACUUCAGUGACUUUGCUGUGGGUGGAAGAGGGAGUAGCUGAUUUCUU… 3703 nt 0.4321
NM_030670.3 NCBI
AGACUUCAGUGACUUUGCUGUGGGUGGAAGAGGGAGUAGCUGAUUUCUU… 4651 nt 0.4356
NM_030671.3 NCBI
AGACUUCAGUGACUUUGCUGUGGGUGGAAGAGGGAGUAGCUGAUUUCUU… 4735 nt 0.4344
Summary

This gene encodes a member of the R3 subtype family of receptor-type protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of cancer. [provided by RefSeq, May 2011]

Forensic Context

A study in cynomolgus monkeys demonstrated that chronic methamphetamine exposure downregulated the PTPRO gene in the hippocampus, while chronic cocaine exposure upregulated it compared to controls [Choi et al. DOI:10.30773/pi.2022.0004]. In mice, perinatal lead exposure was associated with differential expression of genes overlapping with human psychiatric disorder-associated genes, including the PTPRO [Bakulski et al. DOI:10.1093/toxsci/kfaa069].