Basic Information

Symbol
PUM2
RNA class
mRNA
Alias
Pumilio RNA Binding Family Member 2 PUMH2 KIAA0235 Pumilio Homolog 2 Pumilio-2 Pumilio Homolog 2 (Drosophila) PUML2
Location (GRCh38)
2:20248691-20352234
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_015317.5
Sequence length
6309.0 nt
GC content
0.4069

Transcripts

ID Sequence Length GC content
NM_001352927.3 NCBI
AGGGGAGGGCAGGCGGCGGUGGCAGCCAUGUUGUUGUGAGUCUCUGUGU… 6072 nt 0.4045
NM_001352928.3 NCBI
AGGGGAGGGCAGGCGGCGGUGGCAGCCAUGUUGUUGUUUGAUCUGUGGA… 5859 nt 0.3943
NM_001352929.3 NCBI
AGGGGAGGGCAGGCGGCGGUGGCAGCCAUGUUGUUGUGAGUCUCUGUGU… 6197 nt 0.4060
NM_001352930.3 NCBI
AGGGGAGGGCAGGCGGCGGUGGCAGCCAUGUUGUUGUGAGUCUCUGUGU… 6139 nt 0.4069
NM_015317.5 NCBI
AGGGGAGGGCAGGCGGCGGUGGCAGCCAUGUUGUUGUGAGUCUCUGUGU… 6309 nt 0.4069
Showing 11 to 15 of 15 entries
Summary

This gene encodes a protein that belongs to a family of RNA-binding proteins. The encoded protein functions as a translational repressor during embryonic development and cell differentiation. This protein is also thought to be a positive regulator of cell proliferation in adipose-derived stem cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Forensic Context

A study in Sprague-Dawley rats demonstrated that the PUM2 mRNA was used as one of four original genes in an "up, no change, or down" model for wound age estimation in contused skeletal muscle, with its relative expression level simplified to a vector for analysis [Dang et al. DOI:10.1007/s00414-020-02411-z]. In human traumatic brain injury, a top up-regulated circular RNA derived from the parent gene PUM2 was identified, with its expression verified by qRT-PCR in brain injury tissues [Li et al. DOI:10.3389/fneur.2022.1086553].