Basic Information

Symbol
PVALB
RNA class
mRNA
Alias
Parvalbumin Parvalbumin Alpha D22S749 Alpha-Parvalbumin Alpha-PV
Location (GRCh38)
22:36800682-36819479
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Forensic psychiatry evaluation
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001315532.2
Sequence length
550.0 nt
GC content
0.5055

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-146.5 kcal/mol
Thermodynamic ensemble
Free energy: -157 kcal/mol
Frequency: 0.0000
Diversity: 230.63
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
..(((((((((..(((.....))).))))((((((.....(((..((....))..)))..)))))).....((.((((((((.((((((.(((((((........(((........)))........)))).)))))))))....((((.(.(((.(((....((..((((((((....((.(((((.((.......((((...(((..((.(((.(((((((((....))))....))))).))))).)))))))....)))))))))...............(((...(((((((((((.......((((((((.(((........))).))...)))))))))))))))))...)))...))))))))..)).......))).))).)))))..(((..((........))..)))..)))))))).))((((.((((((...(((((........(((((((..........((((.....))))......)))))))........))))))))))).)))).)))))....(((...))).....
Thermodynamic Ensemble Prediction
..{{({(((,{{.{({,...,,{{.{{{((.((((...||||{,|,}|}|||||,,|||||.|,||..{{{((,(((,(((((,....|.|}}.}}.}||||}}|{{(({,.....{{((((({,.,|.(((.((((..........)).)).))).||(((((|......})))))},,{}|||{,}||}}....}|||{..,{{{,,||,|||.{{((((({{..,,}|||....,||||,|||||{},,}||{{{{.|||||||||....,.......,.,}}.||,|||{({.((.{.....(({((((..({{,,,{,{(({((.{{,{{,{{,.|{{,...{||||{.||..(({.,{.,||...,,,|}}..,}}))).,},,,,,.,..|||..{|....,,,.)},.))),,},,,,))),},,|||.|||,,..,}}||})},,}}}.,}||}}|},,,..,..}}||||,,,,.)))),,.,,.,,,)))}.,..,,.,))))....})}.))))}))),,...,|||},.,)),},..

Transcripts

ID Sequence Length GC content
NM_001315532.2 NCBI
ACUUGCUCUGCCCGCUCAAACAGUUGCAGGAUGUCGAUGACAGACUUGC… 550 nt 0.5055
NM_002854.3 NCBI
ACUUCCCGACAGGACUUCCCACCAGCCCAGCCUUUCAGUGCAGGCUCCA… 596 nt 0.5218
Summary

The protein encoded by this gene is a high affinity calcium ion-binding protein that is structurally and functionally similar to calmodulin and troponin C. The encoded protein is thought to be involved in muscle relaxation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

Forensic Context

A study in human autoptic brain tissue demonstrated that the PVALB mRNA, selected for investigation due to its distinct upregulation in the cerebellar region, could not be reliably and repeatedly detected in any of the four examined cerebral cortex lobes (frontal, temporal, parietal, occipital) via multiplex-RT-PCR and capillary electrophoresis [Euteneuer et al. DOI:10.1007/s12024-024-00787-7]. Separately, a transcriptomic analysis of human post-mortem cortical samples noted the PVALB gene as an example where disease effects in psychiatric conditions track cell population balance [Hagenauer et al. DOI:10.1371/journal.pone.0200003].