Basic Information
Symbol
PVR
RNA class
mRNA
Alias
PVR Cell Adhesion Molecule
Poliovirus Receptor
Necl-5
CD155
NECL5
Tage4
HVED
PVS
Nectin-Like Protein 5
Nectin-Like 5
CD155 Antigen
NECL-5
Location (GRCh38)
19:44643798-44666162
Forensic tag(s)
-
MANE select
Transcript ID
NM_006505.5
Sequence length
5792.0 nt
GC content
0.5205
Transcripts
| ID | Sequence | Length | GC content |
|---|---|---|---|
| AGUCACUUGUCUGGAGCUUGAAGAAGUGGGUAUUCCCCUUCCCACCCCA… | 5657 nt | 0.5209 | |
| AGUCACUUGUCUGGAGCUUGAAGAAGUGGGUAUUCCCCUUCCCACCCCA… | 5633 nt | 0.5205 | |
| AGUCACUUGUCUGGAGCUUGAAGAAGUGGGUAUUCCCCUUCCCACCCCA… | 1531 nt | 0.6022 | |
| AGUCACUUGUCUGGAGCUUGAAGAAGUGGGUAUUCCCCUUCCCACCCCA… | 5792 nt | 0.5205 |
Summary
The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Forensic Context
No relevant information is available at the moment.