Basic Information

Symbol
PYCR1
RNA class
mRNA
Alias
Pyrroline-5-Carboxylate Reductase 1 P5C Pyrroline-5-Carboxylate Reductase 1, Mitochondrial P5C Reductase 1 EC 1.5.1.2 Proliferation-Inducing Protein 45 ARCL2B ARCL3B P5CR 1 PIG45 PP222 P5CR PRO3 PYCR
Location (GRCh38)
17:81932378-81942412
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_006907.4
Sequence length
2269.0 nt
GC content
0.6307

Transcripts

ID Sequence Length GC content
NM_001282279.2 NCBI
CUGGGUGCGGGUGCCGCGUGGCGGCCGCAGCGCUGAGGGAGCCGGUGCC… 1776 nt 0.6126
NM_001282280.2 NCBI
CUGGGUGCGGGUGCCGCGUGGCGGCCGCAGCGCUGAGGGAGCCGGUGCC… 1869 nt 0.6158
NM_001282281.2 NCBI
CUGGGUGCGGGUGCCGCGUGGCGGCCGCAGCGCUGAGGGGUGGGUACGA… 1951 nt 0.6222
NM_001330523.2 NCBI
CUGGGUGCGGGUGCCGCGUGGCGGCCGCAGCGCUGAGGGAGCCGGUGCC… 1705 nt 0.6141
NM_006907.4 NCBI
CUGGGUGCGGGUGCCGCGUGGCGGCCGCAGCGCUGAGGGGUGGGUACGA… 2269 nt 0.6307
NM_153824.3 NCBI
CUGGGUGCGGGUGCCGCGUGGCGGCCGCAGCGCUGAGGGGUGGGUACGA… 1926 nt 0.6345
Summary

This gene encodes an enzyme that catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline. This enzyme may also play a physiologic role in the generation of NADP(+) in some cell types. The protein forms a homopolymer and localizes to the mitochondrion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Forensic Context

A study in mice and rats demonstrated that the PYCR1 was identified as a downregulated same-trend differentially expressed gene in the corpus cavernosum of animals with age-related erectile dysfunction, where multi-omics analyses revealed conserved molecular mechanisms involving downregulated mitochondrial activity and extracellular matrix alterations [Long et al. DOI:10.1093/sexmed/qfaf078].