Basic Information

Symbol
PZP
RNA class
mRNA
Alias
PZP Alpha-2-Macroglobulin Like CPAMD6 C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 6 Pregnancy-Zone Protein Pregnancy Zone Protein PZP, Alpha-2-Macroglobulin Like
Location (GRCh38)
12:9148840-9208399
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002864.3
Sequence length
4635.0 nt
GC content
0.4729

Transcripts

ID Sequence Length GC content
NM_002864.3 NCBI
AGGGCGAGGCUGAGGGCAGAGAGUUGGACACAACCCUGAGAUUUAUCCC… 4635 nt 0.4729
Summary

The protein encoded by this gene is highly expressed in late-pregnancy serum and is similar in structure to alpha-2-macroglobulin. The encoded protein, which acts as a homotetramer, inhibits the activity of all four classes of proteinases. This protein contains cleavage sites for several proteinases. Upon binding of a proteinase, the conformation of this protein changes to trap the proteinase, limiting its activity. This protein appears to be elevated in the sera of presymptomatic Alzheimer's disease patients. [provided by RefSeq, Dec 2016]

Forensic Context

No relevant information is available at the moment.