Basic Information

Symbol
QPCT
RNA class
mRNA
Alias
Glutaminyl-Peptide Cyclotransferase QC Glutaminyl Cyclase GCT Glutaminyl-TRNA Cyclotransferase Glutamyl Cyclase EC 2.3.2.5 SQC EC
Location (GRCh38)
2:37342827-37373322
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_012413.4
Sequence length
1683.0 nt
GC content
0.4409

Transcripts

ID Sequence Length GC content
NM_012413.4 NCBI
AGUCGACCCAAGGGUGGAGAAGAGGGAAGGCGAAGGACGCGCGUUCCCG… 1683 nt 0.4409
Summary

This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase. [provided by RefSeq, Jul 2008]

Forensic Context

A study in humans identified the QPCT (QPCT) as a novel core gene for sepsis via weighted correlation network analysis and meta-analysis of public datasets [Wang et al. DOI:10.1371/journal.pone.0317608].