Basic Information

Symbol
QSOX1
RNA class
mRNA
Alias
Quiescin Sulfhydryl Oxidase 1 QSCN6 Quiescin Q6 Sulfhydryl Oxidase 1 Sulfhydryl Oxidase 1 Thiol Oxidase 1 Quiescin Q6 EC 1.8.3.2 Testis Tissue Sperm-Binding Protein Li 62n HQSOX Q6
Location (GRCh38)
1:180154869-180204030
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002826.5
Sequence length
9276.0 nt
GC content
0.5465

Transcripts

ID Sequence Length GC content
NM_001004128.3 NCBI
AUCCGGUGCUUGCGUGUGGUGGUGAGCGCAGCGCCGAGGAUGAGGAGGU… 2547 nt 0.5964
NM_002826.5 NCBI
AUCCGGUGCUUGCGUGUGGUGGUGAGCGCAGCGCCGAGGAUGAGGAGGU… 9276 nt 0.5465
Summary

This gene encodes a protein that contains domains of thioredoxin and ERV1, members of two long-standing gene families. The gene expression is induced as fibroblasts begin to exit the proliferative cycle and enter quiescence, suggesting that this gene plays an important role in growth regulation. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Forensic Context

A study in rhesus macaques identified the QSOX1 as a differentially expressed gene with a consistent mRNA and protein expression pattern in hypertrophic cardiomyopathy, and it was also identified as a polygenic model site with a PIP > 0 in genetic analysis [Rivas et al. DOI:10.1038/s41598-024-82770-4]. In human sepsis research, the QSOX1 was found to be a potential diagnostic biomarker, with its mRNA expression pattern consistent with corresponding protein levels in peripheral blood samples from patients [Wang et al. DOI:10.2147/IDR.S380137].