Basic Information

Symbol
RAB10
RNA class
mRNA
Alias
RAB10, Member RAS Oncogene Family Ras-Related GTP-Binding Protein Ras-Related Protein Rab-10 GTP-Binding Protein RAB10 EC 3.6.5.2
Location (GRCh38)
2:26033481-26138436
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_016131.5
Sequence length
3561.0 nt
GC content
0.4122

Transcripts

ID Sequence Length GC content
NM_016131.5 NCBI
GUCUCAGGCAGCGCGCACGCCGGCGUGAGAGGGCACGGGGAAAAGGUGG… 3561 nt 0.4122
Summary

RAB10 belongs to the RAS (see HRAS; MIM 190020) superfamily of small GTPases. RAB proteins localize to exocytic and endocytic compartments and regulate intracellular vesicle trafficking (Bao et al., 1998 [PubMed 9918381]).[supplied by OMIM, Mar 2009]

Forensic Context

A study in mice demonstrated that the protein level of ras-related protein rab-10 was downregulated by transfection with a mimic of the RAB10 in primary cardiomyocytes, though this effect was not statistically significant [Xue et al. DOI:10.1161/JAHA.122.026160].