Basic Information

Symbol
RAB13
RNA class
mRNA
Alias
RAB13, Member RAS Oncogene Family Cell Growth-Inhibiting Gene 4 Protein Ras-Related Protein Rab-13 Growth-Inhibiting Gene 4 Protein RAS-Associated Protein RAB13 EC 3.6.5.2 GIG4
Location (GRCh38)
1:153981617-153986377
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002870.5
Sequence length
1164.0 nt
GC content
0.5129

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-364.3 kcal/mol
Thermodynamic ensemble
Free energy: -383.82 kcal/mol
Frequency: 0.0000
Diversity: 261.37
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(((((.(((((..(((((.(((((((((.((((((....(((((......((..((((((..(((((((((..(((((..((..((((((..(((((.(((((.((((((..(((.....((((((((...((((.(((.....))).)))).))))))))...((((((((.(((((.(((.((((...((((....))))...............(((((...((((.(((....)))..))))....)))))....)))).)))...)))))....)))))))).......))))))))).).))))....((.((........)).))..))))).))))))..(((((((.((((.(.......((((.(((.((((...(((....)))...))))...)))))))........).)))).))))))).))..))))))))))))))..))))))))......)).)))..((((((...(((((((((((.......))).(((((....)))))(((((((.((.(....).)))))))))((((((.(((..(((((.........)))))..)))..)))))).(((((((((((...((((((.(((((....(((.(((..((..(((...(((.....))))))..)).))).)))....))))).).))))).((.(((......))).)))))))))).)))..))))))))))))))...((((((.........))).))).......)))))).)))))).))).)).......)))....))))).))))).........(((((((((.................................................((((((((((.(((..((.((((.((.(((.((.......(((.((((..((..(((......((((((...((((...((((....((.((.......))))...))))...)))).(((((....)))))...........(.((((.((.((((((((.........)))))))))))))).).)))))).....)))..))...)))).).)).......)).))))).)))).)).))).))....))))))))(((.......))))))))))))......
Thermodynamic Ensemble Prediction
{((((,{((((..{((((.(((((((((.((((((..,,{((((,{{{{.((..{((((,..((((((((({{(((((.,({,,((((((,.(((((.(((((.(((((,.,(((.....((((((((...((((.(((.....))).)))).)))))))).{.((((((((.(((((.(((.(((({..((((....))))..,.........,..(((((...((((.(((....)))..))))....)))))..,.}))).))}...)))))....)))))))).,.....))))))))).).))))....,,.,,........}},||,,,)))).))))))..(((((({.((((.(.......((((.(((.((((.,.(((....)))...))))...)))))))........).)))).})))))}.))..))))}))))))|||,..}}}))))..,...,}.,,}..((((((...(((((((((((.......))),(((((....)))))|((((((.,({(...}),,,)))))),{(((((.(((..(((((.........)))))..)))..)))))},({(((((((((...((((((.(((((....(((.(((..{{..(((...(((.....))))))..)).))).)))....))))).).))))).({.(((......))).)))))))))),,))..)))))))))))))),},|||||{..,,,,..,)}).))),}.,...)))})),)))))).))}.))}.,....,))...,))))).))))),,.......(((((((({....,.......,,,.............,,......|............{(((((((,,,{{(,.((.((({{(({{(((({{...({.,{{.((((..,(..(((...,{{(({{((,,.((((...({{{....,..,........))))...))))..,)))).|||{,.,,,})|||{{.........|}|,{,.{(.((((((((.........)))))))))),}},.,|)))))}...,,))).,))...)))).).)).,...}))).))))).)))).)).))).))....))))))))(((.......))))))))))))......

Transcripts

ID Sequence Length GC content
NM_001272038.2 NCBI
CUCUUCUUUCUUCAUCUCCUCUGGCUUGGGAAAUAGACAGGAAGAGUCU… 1347 nt 0.4684
NM_002870.5 NCBI
CUUCCUGGCCUGGGCUCCGUGCCGCUCUGUUUGCCAACCGUCCAGUCCC… 1164 nt 0.5129
Summary

This gene is a member of the Rab family of small G proteins and plays a role in regulating membrane trafficking between trans-Golgi network (TGN) and recycling endosomes (RE). The encoded protein is involved in the assembly of tight junctions, which are components of the apical junctional complex (AJC) of epithelial cells. The AJC plays a role in forming a barrier between luminal contents and the underlying tissue. Additional functions associated with the protein include endocytic recycling of occludin, regulation of epithelial cell scattering, neuronal regeneration and regulation of neurite outgrowth. Alternately spliced transcript variants have been observed for this gene. A pseudogene associated with this gene is located on chromosome 12. [provided by RefSeq, Jan 2013]

Forensic Context

A study in humans identified the RAB13 as a potential pathogenic biomarker for sepsis, with its expression significantly increased in the peripheral blood mononuclear cells of sepsis patients compared to healthy controls [Shi et al. DOI:10.3389/fimmu.2025.1640425]. Further research in humans confirmed the RAB13 is upregulated in sepsis and its high expression is adversely associated with reduced 28-day survival, with the gene primarily expressed in monocytes [Li et al. DOI:10.1515/biol-2022-0999].