Basic Information

Symbol
RAB3C
RNA class
mRNA
Alias
RAB3C, Member RAS Oncogene Family Ras-Related Protein Rab-3C EC 3.6.5.2
Location (GRCh38)
5:58582221-58859394
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_138453.4
Sequence length
8861.0 nt
GC content
0.3759

Transcripts

ID Sequence Length GC content
NM_001317915.2 NCBI
ACUUCCUAAGAGACUGAGCCCUUUCUCUGCAGCUGCAGCUUGGAUUCCA… 8966 nt 0.3759
NM_138453.4 NCBI
AGUGCUGAUGUUGGAGCCGGUUAGCGAACCCCAAGAGUGCAGAGUGUGG… 8861 nt 0.3759
Summary

This gene is a member of the RAS oncogene family and encodes a small GTPase. Other similar small GTPases are known to be involved in vesicle trafficking, and the encoded protein was shown to play a role in recycling phagocytosed MHC class 1 complexes to the cell surface. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

Forensic Context

A study in humans demonstrated that postmortem midbrain analysis of chronic cocaine abusers identified RAB3C as a diagnostic transcript downregulated -1.4-fold, with its expression performing significantly better than chance in correctly assigning subjects to the cocaine abuse cohort [Bannon et al. DOI:10.1038/Npp.2014.70].