Basic Information

Symbol
RAB6A
RNA class
mRNA
Alias
RAB6A, Member RAS Oncogene Family RAB6 Ras-Related Protein Rab-6A RAB6, Member RAS Oncogene Family Rab GTPase EC 3.6.5.2 Rab-6
Location (GRCh38)
11:73675638-73761465
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Chronological age estimation Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_198896.2
Sequence length
3326.0 nt
GC content
0.4077

Transcripts

ID Sequence Length GC content
NM_001243718.2 NCBI
ACUCAGCAGGUUGGGCUGCGGCGGCGGCGGCAGCUGUGGAAGCUCAGGC… 3014 nt 0.4078
NM_001243719.2 NCBI
UUGUUUUCCCCAGAGGCUUGGCCCUGCGAAGUGCUGAUGUCGUGGAAGU… 2865 nt 0.3634
NM_002869.5 NCBI
ACUCAGCAGGUUGGGCUGCGGCGGCGGCGGCAGCUGUGGAAGCUCAGGC… 3326 nt 0.4089
NM_198896.2 NCBI
ACUCAGCAGGUUGGGCUGCGGCGGCGGCGGCAGCUGUGGAAGCUCAGGC… 3326 nt 0.4077
Summary

This gene encodes a member of the RAB family, which belongs to the small GTPase superfamily. GTPases of the RAB family bind to various effectors to regulate the targeting and fusion of transport carriers to acceptor compartments. This protein is located at the Golgi apparatus, which regulates trafficking in both a retrograde (from early endosomes and Golgi to the endoplasmic reticulum) and an anterograde (from the Golgi to the plasma membrane) directions. Myosin II is an effector of this protein in these processes. This protein is also involved in assembly of human cytomegalovirus (HCMV) by interacting with the cellular protein Bicaudal D1, which interacts with the HCMV virion tegument protein, pp150. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Forensic Context

A study in humans using RNA-Seq data from dried blood stains and whole blood identified the RAB6A as a candidate mRNA marker for age estimation, with its expression decreasing with age in the RNAgE data set. The research employed lasso regression and DESeq2 analysis to select age-associated genes, and a model using a lasso-selected gene list, which included the RAB6A, achieved a mean absolute error of 4.46 years for age prediction in the RNAgE cohort [Dørum et al. DOI:10.1016/j.fsigen.2023.102976]. A study in mice demonstrated that the RAB6A gene was significantly enhanced in brain tissue following 25 minutes of neck ligation-induced hypoxia, both immediately and 30 minutes post-mortem, as confirmed by fluorescence differential display PCR, comparative RT-PCR, and statistical analysis (ANOVA) [Ikematsu et al. DOI:10.1016/J.Forsciint.2006.08.015]. This specific expression pattern, not observed in control groups or after brief hypoxia, associates the RAB6A with extended hypoxic conditions and vital cellular functions like intracellular signaling, contributing to the pathophysiological understanding and diagnostic assessment of suffocation.