Basic Information

Symbol
RABGGTB
RNA class
mRNA
Alias
Rab Geranylgeranyltransferase Subunit Beta Type II Protein Geranyl-Geranyltransferase Subunit Beta Geranylgeranyl Transferase Type-2 Subunit Beta Rab GG Transferase Beta Rab GGTase Beta GGTase-II-Beta EC 2.5.1.60 GGTB Geranylgeranyl Transferase Type II Subunit Beta Rab Geranyl-Geranyltransferase Subunit Beta Rab Geranylgeranyltransferase Beta Subunit
Location (GRCh38)
1:75786188-75795086
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_004582.4
Sequence length
1448.0 nt
GC content
0.3722

Transcripts

ID Sequence Length GC content
NM_004582.4 NCBI
CCUUUCCCUGUUAGACAUGGGCACUCCACAGAAGGAUGUUAUUAUCAAG… 1448 nt 0.3722
Summary

This gene encodes the beta-subunit of the enzyme Rab geranylgeranyl-transferase (RabGGTase), which belongs to the protein prenyltransferase family. RabGGTase catalyzes the post-translational addition of geranylgeranyl groups to C-terminal cysteine residues of Rab GTPases. Three small nucleolar RNA genes are present in the intronic regions of this gene. Alternately spliced transcript variants have been observed for this gene. A pseudogene associated with this gene is located on chromosome 3. [provided by RefSeq, Jan 2013]

Forensic Context

A study in mice demonstrated that the RABGGTB was identified as a network hub node among ventral midbrain (VMB) differentially expressed genes overexpressed in the methamphetamine high drinking (MAHDR) line, specifically within the black coexpression module, indicating its role in the transcriptomic network associated with differential genetic risk for voluntary methamphetamine intake [Hitzemann et al. DOI:10.3390/brainsci9070155].