Basic Information

Symbol
RAC1
RNA class
mRNA
Alias
Rac Family Small GTPase 1 P21-Rac1 TC-25 Rac-1 Ras-Related C3 Botulinum Toxin Substrate 1 (Rho Family, Small GTP Binding Protein Rac1) Ras-Related C3 Botulinum Toxin Substrate 1 Cell Migration-Inducing Gene 5 Protein Ras-Like Protein TC25 EC 3.6.5.2 MRD48 MIG5 TC25
Location (GRCh38)
7:6374098-6403998
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_006908.5
Sequence length
2309.0 nt
GC content
0.4465

Transcripts

ID Sequence Length GC content
NM_006908.5 NCBI
CUGUUUCUCUGCAGUUUUCCUCAGCUUUGGGUGGUGGCCGCUGCCGGGC… 2309 nt 0.4465
NM_018890.4 NCBI
CUGUUUCUCUGCAGUUUUCCUCAGCUUUGGGUGGUGGCCGCUGCCGGGC… 2366 nt 0.4484
Summary

The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009] CIViC Summary for RAC1 Gene The RAC1 P29S mutation is the third most common protein-coding hotspot mutation in melanomas, ocurring in 4-9%. A preclinical study has shown that this mutation confers resistance to BRAF inhibition in-vitro.

Forensic Context

A study in mice demonstrated that the RAC1 was upregulated in common in white blood cells at day 1 post-injury following both burn and trauma-hemorrhage, where it was identified as a gene expression marker associated with the cell death pathway [Lederer et al. DOI:10.1152/physiolgenomics.00086.2007].