Basic Information

Symbol
RAC2
RNA class
mRNA
Alias
Rac Family Small GTPase 2 EN-7 Ras-Related C3 Botulinum Toxin Substrate 2 (Rho Family, Small GTP Binding Protein Rac2) Ras-Related C3 Botulinum Toxin Substrate 2 Small G Protein P21-Rac2 Ras-Related C3 Botulinum Toxin Substrate 3 (Rho Family, Small GTP-Binding Protein Rac2) EC 3.6.5.2 HSPC022 IMD73A IMD73B IMD73C Gx GX
Location (GRCh38)
22:37225270-37259594
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002872.5
Sequence length
1472.0 nt
GC content
0.5747

Transcripts

ID Sequence Length GC content
NM_002872.5 NCBI
CUCCUGCCCCACCACCGCUGCUCCUCAGCAGGCGCCUCACCAGCCUCCA… 1472 nt 0.5747
Summary

This gene encodes a member of the Ras superfamily of small guanosine triphosphate (GTP)-metabolizing proteins. The encoded protein localizes to the plasma membrane, where it regulates diverse processes, such as secretion, phagocytosis, and cell polarization. Activity of this protein is also involved in the generation of reactive oxygen species. Mutations in this gene are associated with neutrophil immunodeficiency syndrome. There is a pseudogene for this gene on chromosome 6. [provided by RefSeq, Jul 2013]

Forensic Context

A study in mice demonstrated that ethanol exposure during neural stem cell differentiation significantly down-regulated the expression of the RAC2 gene, which is a component of the Wnt signaling pathway, as confirmed by microarray and qRT-PCR analyses [Mandal et al. DOI:10.1007/S11033-015-3862-1].