Basic Information

Symbol
RACGAP1
RNA class
mRNA
Alias
Rac GTPase Activating Protein 1 MgcRacGAP CYK4 Rac GTPase-Activating Protein 1 Male Germ Cell RacGap Protein CYK4 Homolog HsCYK-4 MGCRACGAP KIAA1478 CDAN3B ID-GAP RCGAP1
Location (GRCh38)
12:49976923-50033136
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001319999.2
Sequence length
3106.0 nt
GC content
0.4482

Transcripts

ID Sequence Length GC content
NM_001126103.3 NCBI
GUUUUCAAACCGGAGCUGUGGGCGCGGCGCUGCUCUGCCGUUGGGUGAG… 3296 nt 0.4454
NM_001126104.3 NCBI
GUUUUCAAACCGGAGCUGUGGGCGCGGCGCUGCUCUGCCGUUGGGUGAG… 3176 nt 0.4512
NM_001319999.2 NCBI
GUUUUCAAACCGGAGCUGUGGGCGCGGCGCUGCUCUGCCGUUGGGUGAG… 3106 nt 0.4482
NM_001320000.2 NCBI
GUUUUCAAACCGGAGCUGUGGGCGCGGCGCUGCUCUGCCGUUGGGUGAG… 3180 nt 0.4484
NM_001320001.2 NCBI
GUUUUCAAACCGGAGCUGUGGGCGCGGCGCUGCUCUGCCGUUGGGUGAG… 3172 nt 0.4515
NM_001320002.2 NCBI
GUUUUCAAACCGGAGCUGUGGGCGCGGCGCUGCUCUGCCGUUGGGUGAG… 3131 nt 0.4497
NM_001320003.2 NCBI
GUUUUCAAACCGGAGCUGUGGGCGCGGCGCUGCUCUGCCGUUGGGUGAG… 3102 nt 0.4484
NM_001320004.2 NCBI
GUUUUCAAACCGGAGCUGUGGGCGCGGCGCUGCUCUGCCGUUGGAAAGA… 3053 nt 0.4442
NM_001320005.2 NCBI
GUUUUCAAACCGGAGCUGUGGGCGCGGCGCUGCUCUGCCGUUGGGUGAG… 3017 nt 0.4475
NM_001320006.2 NCBI
GUUUUCAAACCGGAGCUGUGGGCGCGGCGCUGCUCUGCCGUUGGGUGAG… 3176 nt 0.4487
Showing 1 to 10 of 12 entries
Summary

This gene encodes a GTPase-activating protein (GAP) that is a compoment of the centralspindlin complex. This protein binds activated forms of Rho GTPases and stimulates GTP hydrolysis, which results in negative regulation of Rho-mediated signals. This protein plays a regulatory role in cytokinesis, cell growth, and differentiation. Alternatively spliced transcript variants have been found for this gene. There is a pseudogene for this gene on chromosome 12. [provided by RefSeq, Feb 2016]

Forensic Context

A study in mice demonstrated that the RACGAP1 was upregulated in the corpus callosum-external capsule at 2 days post-traumatic brain injury, where it was identified as a unique differentially expressed gene [Kounelis-Wuillaume et al. DOI:10.1177/08977151251390528]. In rhesus macaques with radiation-induced lung injury, transcriptomic analysis identified the RACGAP1 as a downregulated transcript specifically in survivor-specific differential gene expression, associated with processes related to cell-cycle regulation and repair [Thakur et al. DOI:10.1016/j.ijrobp.2021.03.058].