Basic Information

Symbol
RACGAP1
RNA class
mRNA
Alias
Rac GTPase Activating Protein 1 MgcRacGAP CYK4 Rac GTPase-Activating Protein 1 Male Germ Cell RacGap Protein CYK4 Homolog HsCYK-4 MGCRACGAP KIAA1478 CDAN3B ID-GAP RCGAP1
Location (GRCh38)
12:49976923-50033136
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001319999.2
Sequence length
3106.0 nt
GC content
0.4482

Transcripts

ID Sequence Length GC content
NM_001320007.2 NCBI
GUUUUCAAACCGGAGCUGUGGGCGCGGCGCUGCUCUGCCGUUGGGUGAG… 2903 nt 0.4468
NM_013277.5 NCBI
GUUUUCAAACCGGAGCUGUGGGCGCGGCGCUGCUCUGCCGUUGGGUGAG… 3285 nt 0.4426
Showing 11 to 12 of 12 entries
Summary

This gene encodes a GTPase-activating protein (GAP) that is a compoment of the centralspindlin complex. This protein binds activated forms of Rho GTPases and stimulates GTP hydrolysis, which results in negative regulation of Rho-mediated signals. This protein plays a regulatory role in cytokinesis, cell growth, and differentiation. Alternatively spliced transcript variants have been found for this gene. There is a pseudogene for this gene on chromosome 12. [provided by RefSeq, Feb 2016]

Forensic Context

A study in mice demonstrated that the RACGAP1 was upregulated in the corpus callosum-external capsule at 2 days post-traumatic brain injury, where it was identified as a unique differentially expressed gene [Kounelis-Wuillaume et al. DOI:10.1177/08977151251390528]. In rhesus macaques with radiation-induced lung injury, transcriptomic analysis identified the RACGAP1 as a downregulated transcript specifically in survivor-specific differential gene expression, associated with processes related to cell-cycle regulation and repair [Thakur et al. DOI:10.1016/j.ijrobp.2021.03.058].