Basic Information

Symbol
RAD23A
RNA class
mRNA
Alias
RAD23 Nucleotide Excision Repair Protein A HHR23A RAD23 Homolog A, Nucleotide Excision Repair Protein UV Excision Repair Protein RAD23 Homolog A RAD23, Yeast Homolog, A MGC111083 HR23A RAD23 (S. Cerevisiae) Homolog A RAD23 Homolog A (S. Cerevisiae)
Location (GRCh38)
19:12945848-12953646
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_005053.4
Sequence length
1772.0 nt
GC content
0.5807

Transcripts

ID Sequence Length GC content
NM_001270362.2 NCBI
GCGGCGCGCCUGGGCGCUAAGAUGGCGGCGGCGUGAGUUGCAUGUUGUG… 1769 nt 0.5806
NM_001270363.2 NCBI
GCGGCGCGCCUGGGCGCUAAGAUGGCGGCGGCGUGAGUUGCAUGUUGUG… 1607 nt 0.5781
NM_005053.4 NCBI
GCGGCGCGCCUGGGCGCUAAGAUGGCGGCGGCGUGAGUUGCAUGUUGUG… 1772 nt 0.5807
Summary

The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair. Proteins in this family have a modular domain structure consisting of an ubiquitin-like domain (UbL), ubiquitin-associated domain 1 (UbA1), XPC-binding domain and UbA2. The protein encoded by this gene plays an important role in nucleotide excision repair and also in delivery of polyubiquitinated proteins to the proteasome. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012]

Forensic Context

A study in rats demonstrated that the RAD23A mRNA was upregulated at 2 and 24 hours after a 14–15 psi blast exposure, indicating its involvement in DNA repair pathways following severe blast-induced traumatic brain injury [Balaban et al. DOI:10.1016/j.jneumeth.2016.02.001]. A study in humans demonstrated that the RAD23A exhibited a Gini impurity score of 0 for peripheral blood classification, being present in some pure blood samples but absent in mixtures containing blood and without blood [Shehata et al. DOI:10.1016/j.fsigen.2025.103343].