Basic Information
MANE select
Transcripts
| ID | Sequence | Length | GC content |
|---|---|---|---|
| AAUUCUGAAAGCCGCUGGCGGACCGCGCGCAGCGGCCAGAGACCGAGCC… | 2335 nt | 0.4668 | |
| AAUUCUGAAAGCCGCUGGCGGACCGCGCGCAGCGGCCAGAGACCGAGCC… | 2314 nt | 0.4745 | |
| AAUUCUGAAAGCCGCUGGCGGACCGCGCGCAGCGGCCAGAGACCGAGCC… | 2436 nt | 0.4737 | |
| AAUUCUGAAAGCCGCUGGCGGACCGCGCGCAGCGGCCAGAGACCGAGCC… | 2439 nt | 0.4797 |
Summary
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
Forensic Context
A study in humans using RNA-Seq data from PBMCs of mustard gas-exposed individuals identified the RAD51 as a potential diagnostic and severity biomarker, with notable upregulation in the Severe injury group compared to other groups [Arabfard et al. DOI:10.1016/j.intimp.2025.114090].