Basic Information

Symbol
RAD9A
RNA class
mRNA
Alias
RAD9 Checkpoint Clamp Component A Cell Cycle Checkpoint Control Protein RAD9A DNA Repair Exonuclease Rad9 Homolog A HRAD9 RAD9 RAD9 Homolog A (S. Pombe) RAD9 (S. Pombe) Homolog RAD9 Homolog A EC 3.1.11.2
Location (GRCh38)
11:67317871-67398410
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_004584.3
Sequence length
2086.0 nt
GC content
0.6021

Transcripts

ID Sequence Length GC content
NM_001243224.1 NCBI
AGGUCUUUCAAGGCAUUCCAAGCAUAAGGAAGAGCAUGAAUGAGGCCUA… 1992 nt 0.5873
NM_004584.3 NCBI
GGACCCGGAGGUCGCGGAGAGCUGGGCAGUGUUGGCCGCUGGCGGAGCG… 2086 nt 0.6021
Summary

This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair. This protein possesses 3' to 5' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Forensic Context

A study in mice demonstrated that the RAD9A mRNA was down-regulated (0.31-fold) in bone marrow cells 6 hours after 6.5 Gy whole-body irradiation [Dai et al. DOI:10.1080/09553000600857389]. In primary human lung microvascular endothelial cells, RNA-seq analysis showed the RAD9A mRNA was down-regulated 1.6-fold at 24 hours following 10 Gy X-irradiation [Bouten et al. DOI:10.1038/s41598-021-03636-7].