Basic Information

Symbol
RAF1
RNA class
mRNA
Alias
Raf-1 Proto-Oncogene, Serine/Threonine Kinase Raf-1 C-Raf CRAF RAF Proto-Oncogene Serine/Threonine-Protein Kinase V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 C-Raf Proto-Oncogene, Serine/Threonine Kinase Proto-Oncogene C-RAF EC 2.7.11.1 V-Raf-1 Murine Leukemia Viral Oncogene-Like Protein 1 Raf Proto-Oncogene Serine/Threonine Protein Kinase Oncogene RAF1 EC 2.7.11 CMD1NN CRaf NS5 RAF
Location (GRCh38)
3:12582101-12664201
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002880.4
Sequence length
3191.0 nt
GC content
0.5067

Transcripts

ID Sequence Length GC content
NM_001354689.3 NCBI
AAUCGCGGGCGCUUGGGCCGCCAUCUUAGAUGGCGGGAGUAAGAGGAAA… 3251 nt 0.5066
NM_001354690.3 NCBI
AGAGCUGCCCCAUAUCUGUUGUCACUUGGAUGGGCCAAUUCCUUUUCUC… 3026 nt 0.4898
NM_001354691.3 NCBI
AAUCGCGGGCGCUUGGGCCGCCAUCUUAGAUGGCGGGAGUAAGAGGAAA… 3171 nt 0.5077
NM_001354692.3 NCBI
AAUCGCGGGCGCUUGGGCCGCCAUCUUAGAUGGCGGGAGUAAGAGGAAA… 3078 nt 0.5068
NM_001354693.3 NCBI
AAUCGCGGGCGCUUGGGCCGCCAUCUUAGAUGGCGGGAGUAAGAGGAAA… 3092 nt 0.5084
NM_001354694.3 NCBI
AAUCGCGGGCGCUUGGGCCGCCAUCUUAGAUGGCGGGAGUAAGAGGAAA… 3138 nt 0.5067
NM_001354695.3 NCBI
AAUCGCGGGCGCUUGGGCCGCCAUCUUAGAUGGCGGGAGUAAGAGGAAA… 2979 nt 0.5086
NM_002880.4 NCBI
AAUCGCGGGCGCUUGGGCCGCCAUCUUAGAUGGCGGGAGUAAGAGGAAA… 3191 nt 0.5067
Summary

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008] CIViC Summary for RAF1 Gene

Forensic Context

No relevant information is available at the moment.