Basic Information

Symbol
RALGDS
RNA class
mRNA
Alias
Ral Guanine Nucleotide Dissociation Stimulator RalGEF RGF RGDS Ral Guanine Nucleotide Exchange Factor KIAA1308 RalGDS
Location (GRCh38)
9:133097719-133149334
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_006266.4
Sequence length
3696.0 nt
GC content
0.5998

Transcripts

ID Sequence Length GC content
NM_001042368.3 NCBI
GGCGAGGCCCGAGCGGCCGGAGCGCGGCGCGGCGCAGACAAUGGGAGCG… 3675 nt 0.5992
NM_001271774.2 NCBI
GCUCAGAGGAGCAGGGCUGGGAGCGAGGUGCUGCUGGGGCAGUGUCUGG… 3597 nt 0.5908
NM_001271775.2 NCBI
ACUCCACUAGGGCACGCAGGCGACGAGCACACUGGCAGAGGGCCUCCCG… 3690 nt 0.5919
NM_001271776.2 NCBI
AGCGGUGGCAAAGCCCAGCCGCGCGGGCCGCGCCGCCGCCCCCGCCGCG… 3660 nt 0.5997
NM_006266.4 NCBI
AGCGGUGGCAAAGCCCAGCCGCGCGGGCCGCGCCGCCGCCCCCGCCGCG… 3696 nt 0.5998
Summary

Guanine nucleotide dissociation stimulators (GDSs, or exchange factors), such as RALGDS, are effectors of Ras-related GTPases (see MIM 190020) that participate in signaling for a variety of cellular processes.[supplied by OMIM, Nov 2010]

Forensic Context

A study in rhesus macaques identified the RALGDS as a differentially expressed gene that was upregulated in animals with hypertrophic cardiomyopathy, where its expression pattern was better explained by a statistical model incorporating both disease condition and age rather than condition alone [Rivas et al. DOI:10.1038/s41598-024-82770-4].