Basic Information

Symbol
RANBP1
RNA class
mRNA
Alias
RAN Binding Protein 1 HTF9A Ran-Specific GTPase-Activating Protein Testis Secretory Sperm-Binding Protein Li 221n HpaII Tiny Fragments Locus 9A Ran-Binding Protein 1 RanBP1
Location (GRCh38)
22:20115877-20127355
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001278639.2
Sequence length
1221.0 nt
GC content
0.4881

Transcripts

ID Sequence Length GC content
NM_001278639.2 NCBI
ACUGUCCAUAGAGGGGUCACCACGUCGGCCACUCGUGUUACUGGUGGCU… 1221 nt 0.4881
NM_001278640.2 NCBI
GUUCGGGUCGUGGGGCGGAGGGAAGAGCGGGCGGGCGGGAGGCGCCGGC… 1051 nt 0.4900
NM_001278641.2 NCBI
GCCGCCACCAACCUCCGCCGGCCUGCAGGCUCGGCCGUCUGCUGGGCCU… 1460 nt 0.5226
NM_002882.4 NCBI
GUUCGGGUCGUGGGGCGGAGGGAAGAGCGGGCGGGCGGGAGGCGCCGGC… 1054 nt 0.4905
Summary

This gene encodes a protein that forms a complex with Ras-related nuclear protein (Ran) and metabolizes guanoside triphosphate (GTP). This complex participates in the regulation of the cell cycle by controlling transport of proteins and nucleic acids into the nucleus. There are multiple pseudogenes for this gene on chromosomes 9, 12, 17, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Forensic Context

A study in mice demonstrated that the RANBP1 is a marker for cycling B-cells, being enriched in the cycling B-cell subpopulation (Cyc) identified via single-cell RNA sequencing analysis of cardiac and mediastinal lymph node B cells following myocardial infarction [Bian et al. DOI:10.3892/mmr.2025.13680].