Basic Information

Symbol
RANBP2
RNA class
mRNA
Alias
RAN Binding Protein 2 NUP358 ADANE Acute Necrotizing Encephalopathy 1 (Autosomal Dominant) Nuclear Pore Complex Protein Nup358 E3 SUMO-Protein Ligase RanBP2 Ran-Binding Protein 2 358 KDa Nucleoporin Nucleoporin Nup358 Nucleoporin 358 ANE1 P270 E3 SUMO-Protein Transferase RanBP2 Transformation-Related Protein 2 EC 2.3.2.- EC 5.2.1.8 RanBP2 IIAE3 TRP1 TRP2
Location (GRCh38)
2:108719437-108785810
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_006267.5
Sequence length
11708.0 nt
GC content
0.3919

Transcripts

ID Sequence Length GC content
NM_001415871.1 NCBI
ACAGUGGUCCUCCGCCGGCUACGGCGCUGCGUCACUGGUUUGCAGGCGC… 11786 nt 0.3921
NM_001415872.1 NCBI
ACAGUGGUCCUCCGCCGGCUACGGCGCUGCGUCACUGGUUUGCAGGCGC… 11705 nt 0.3919
NM_001415873.1 NCBI
ACAGUGGUCCUCCGCCGGCUACGGCGCUGCGUCACUGGUUUGCAGGCGC… 11732 nt 0.3918
NM_006267.5 NCBI
ACAGUGGUCCUCCGCCGGCUACGGCGCUGCGUCACUGGUUUGCAGGCGC… 11708 nt 0.3919
Summary

RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q. [provided by RefSeq, Jul 2008]

Forensic Context

A study in rats demonstrated that the RANBP2 (RAN binding protein 2) was identified as a potential regulator of methamphetamine reward and addiction through transcriptome profiling of whisker follicles, showing a down-up regulated expression pattern (0.77-fold after self-administration and 1.39-fold after withdrawal) and a betweenness centrality score of 0.0671 within a functional association network of 43 prioritized genes [Song et al. DOI:10.1038/s41598-018-29772-1].