Basic Information

Symbol
RAP1A
RNA class
mRNA
Alias
RAP1A, Member Of RAS Oncogene Family KREV-1 SMGP21 GTP-Binding Protein Smg P21A Ras-Related Protein Rap-1A Ras-Related Protein Krev-1 C21KG G-22K KREV1 EC 3.6.5.2 RAP1
Location (GRCh38)
1:111542218-111716691
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002884.4
Sequence length
5018.0 nt
GC content
0.3776

Transcripts

ID Sequence Length GC content
NM_001010935.3 NCBI
GCCGCCGCUCCCGAGGCCCCUGCCGCCGCCGCUCCCGCUGCUGUCGCCG… 5112 nt 0.3789
NM_001291896.3 NCBI
GCCGCCGCUCCCGAGGCCCCUGCCGCCGCCGCUCCCGCUGCUGUCGCCG… 5431 nt 0.4038
NM_001370216.2 NCBI
AUUCAUUCCAUAAGCAUUCCUUUCUUUAAAGAGGAAUACCUCUCUUAAC… 5373 nt 0.3720
NM_001370217.2 NCBI
GCCGCCGCUCCCGAGGCCCCUGCCGCCGCCGCUCCCGCUGCUGUCGCCG… 5098 nt 0.3780
NM_001394066.1 NCBI
GCCGCCGCUCCCGAGGCCCCUGCCGCCGCCGCUCCCGCUGCUGUCGCCG… 5192 nt 0.3792
NM_002884.4 NCBI
GCCGCCGCUCCCGAGGCCCCUGCCGCCGCCGCUCCCGCUGCUGUCGCCG… 5018 nt 0.3776
Summary

This gene encodes a member of the Ras family of small GTPases. The encoded protein undergoes a change in conformational state and activity, depending on whether it is bound to GTP or GDP. This protein is activated by several types of guanine nucleotide exchange factors (GEFs), and inactivated by two groups of GTPase-activating proteins (GAPs). The activation status of the encoded protein is therefore affected by the balance of intracellular levels of GEFs and GAPs. The encoded protein regulates signaling pathways that affect cell proliferation and adhesion, and may play a role in tumor malignancy. Pseudogenes of this gene have been defined on chromosomes 14 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Forensic Context

A study in brown rats (Rattus norvegicus) demonstrated that the RAP1A is a top hub gene in the neurotrophin signaling pathway, enriched among co-regulated target genes following spinal cord injury [Liu et al. DOI:10.1097/BRS.0000000000001323]. In porcine (Sus scrofa) skin exposed to bromine, the RAP1A showed differential expression, being decreased at 45 s–24 h, 45 s–7 d, and 8 min–7 d but increased at 8 min–24 h, and was involved in multiple signaling pathways including ERK/MAPK and axonal guidance [Price et al. DOI:10.1016/j.toxlet.2008.08.007].