Basic Information

Symbol
RAP1B
RNA class
mRNA
Alias
RAP1B, Member Of RAS Oncogene Family K-REV RAL1B GTP-Binding Protein Smg P21B Ras-Related Protein Rap-1b DKFZp586H0723 Ras Family Small GTP Binding Protein RAP1B RAS-Related Protein RAP1B Small GTP Binding Protein EC 3.6.5.2 THC11
Location (GRCh38)
12:68610410-68671901
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001010942.3
Sequence length
13378.0 nt
GC content
0.3770

Transcripts

ID Sequence Length GC content
NM_001010942.3 NCBI
GACAUCGCCAAACCUCGCCCAGAUUCAGGCGUGUAAACCAGCCGGAGCG… 13378 nt 0.3770
NM_001251917.2 NCBI
GACAUCGCCAAACCUCGCCCAGAUUCAGGCGUGUAAACCAGCCGGAGCG… 13261 nt 0.3774
NM_001251918.2 NCBI
GACAUCGCCAAACCUCGCCCAGAUUCAGGCGUGUAAACCAGCCGGAGCG… 13252 nt 0.3773
NM_001251921.2 NCBI
GACAUCGCCAAACCUCGCCCAGAUUCAGGCGUGUAAACCAGCCGGAGCG… 13321 nt 0.3768
NM_001251922.2 NCBI
GACAUCGCCAAACCUCGCCCAGAUUCAGGCGUGUAAACCAGCCGGAGCG… 13237 nt 0.3772
NM_015646.6 NCBI
GACAUCGCCAAACCUCGCCCAGAUUCAGGCGUGUAAACCAGCCGGAGCG… 13387 nt 0.3772
Summary

This gene encodes a member of the RAS-like small GTP-binding protein superfamily. Members of this family regulate multiple cellular processes including cell adhesion and growth and differentiation. This protein localizes to cellular membranes and has been shown to regulate integrin-mediated cell signaling. This protein also plays a role in regulating outside-in signaling in platelets. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 5, 6 and 9. [provided by RefSeq, Oct 2011]

Forensic Context

A bioinformatics study in adult female Wistar rats (Rattus norvegicus) identified 68 time-course differentially expressed microRNAs after spinal cord injury, with synergetic analysis revealing 193 co-regulated target genes enriched in nervous system development and key hub genes like AKT1, VEGFA, and BDNF being part of the neurotrophin signaling pathway [Liu et al. DOI:10.1097/BRS.0000000000001323].