Basic Information

Symbol
RAP1GAP2
RNA class
mRNA
Alias
RAP1 GTPase Activating Protein 2 KIAA1039 GARNL4 GTPase-Activating Rap/Ran-GAP Domain-Like Protein 4 GTPase Activating Rap/RanGAP Domain-Like 4 GTPase Activating RANGAP Domain-Like 4 Rap1 GTPase-Activating Protein 2 Rap1GAP2 RAP1GA3 RAP1GA2
Location (GRCh38)
17:2755705-3037741
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Time since deposition estimation
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_015085.5
Sequence length
6663.0 nt
GC content
0.5601

Transcripts

ID Sequence Length GC content
NM_001100398.2 NCBI
ACUGACCCCGCUGUACCACGGCCCUCUUGCGGACAGCCCCGGGGACGUC… 6618 nt 0.5601
NM_001330058.2 NCBI
GUGCGCUGGGGCCGGCCGGGGUGCGCGCGUGCGCGGCAGGACUGCUGCG… 6719 nt 0.5645
NM_001411048.1 NCBI
GGACACCCGCCUGCGGCAGCCGAGCCUCCUCCACCGUGCGGCCCGCGGA… 6769 nt 0.5640
NM_001411049.1 NCBI
GCGGGCGGCGCGUCUGAGCGGGAGCCGGGAGCCGCCGGCCCGGGCCGCG… 6912 nt 0.5723
NM_015085.5 NCBI
ACUGACCCCGCUGUACCACGGCCCUCUUGCGGACAGCCCCGGGGACGUC… 6663 nt 0.5601
Summary

This gene encodes a GTPase-activating protein that activates the small guanine-nucleotide-binding protein Rap1 in platelets. The protein interacts with synaptotagmin-like protein 1 and Rab27 and regulates secretion of dense granules from platelets at sites of endothelial damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Forensic Context

A study in humans demonstrated that the RAP1GAP2 exhibits temporal degradation in semen over a period of 0 to 1.5 years, identifying it as a biomarker for estimating the time since deposition of forensic biological samples [Lei et al. DOI:10.1093/gpbjnl/qzag007].