Basic Information

Symbol
RAPGEF1
RNA class
mRNA
Alias
Rap Guanine Nucleotide Exchange Factor 1 GRF2 C3G Guanine Nucleotide-Releasing Factor 2 (Specific For Crk Proto-Oncogene) Rap Guanine Nucleotide Exchange Factor (GEF) 1 CRK SH3-Binding GNRP Guanine Nucleotide-Releasing Factor 2 Protein C3G
Location (GRCh38)
9:131576758-131740117
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001377935.1
Sequence length
6760.0 nt
GC content
0.5862

Transcripts

ID Sequence Length GC content
NM_001304275.2 NCBI
GUCGCUGCGCUGCGGCCGGCUCGCGGGCCGGGGGAGCGGCGGCGGGCGC… 6253 nt 0.5868
NM_001377935.1 NCBI
GUCGCUGCGCUGCGGCCGGCUCGCGGGCCGGGGGAGCGGCGGCGGGCGC… 6760 nt 0.5862
NM_001377936.1 NCBI
UUCAGUCACCGCUGCCAACUCCAGAGCCUUGCACAUGUCACUUGUUGCA… 6113 nt 0.5699
NM_001377937.1 NCBI
GUCGCUGCGCUGCGGCCGGCUCGCGGGCCGGGGGAGCGGCGGCGGGCGC… 6139 nt 0.5877
NM_001377938.1 NCBI
GUCGCUGCGCUGCGGCCGGCUCGCGGGCCGGGGGAGCGGCGGCGGGCGC… 6649 nt 0.5872
NM_005312.4 NCBI
ACCCAGGCUGCCAGACCGAGCGACCGUGCUGCCAUGGACACAGACUCUC… 5989 nt 0.5741
NM_198679.2 NCBI
GAGAUUCCUCAGGCUUCCCUUGUGAGGCUGCCUGGGUUCUGCCGCUGGG… 6169 nt 0.5722
Summary

This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]

Forensic Context

A study in human forensic autopsy cases using RNA sequencing demonstrated that the RAPGEF1 was upregulated in a case of fatal insulin overdose, where it functioned as an additional adaptor/signaling molecule within the insulin signaling pathway [Nakao et al. DOI:10.1016/j.legalmed.2025.102772].