Basic Information

Symbol
RAPGEF3
RNA class
mRNA
Alias
Rap Guanine Nucleotide Exchange Factor 3 CAMP-GEFI EPAC Exchange Protein Directly Activated By CAMP 1 Bcm910 Rap1 Guanine-Nucleotide-Exchange Factor Directly Activated By CAMP CAMP-Regulated Guanine Nucleotide Exchange Factor I Rap Guanine Nucleotide Exchange Factor (GEF) 3 Exchange Factor Directly Activated By CAMP 1 EPAC 1 EPAC1 RAP Guanine-Nucleotide-Exchange Factor (GEF) 3 9330170P05Rik HSU79275 CGEF1
Location (GRCh38)
12:47734363-47771040
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001098531.4
Sequence length
6300.0 nt
GC content
0.5949

Transcripts

ID Sequence Length GC content
NM_001098531.4 NCBI
AGCGCAGCCUUGCUUCAGCGCCCGGUGCCAGCUGGCUCCUUCGUCUGAG… 6300 nt 0.5949
NM_001098532.2 NCBI
AGUGAAUCUAUAGCUUCAUACUGGGAGGUAGUGGAGAUCCCUGCAGGGG… 6003 nt 0.5977
NM_006105.5 NCBI
GUUAGUCAGGGCUGAGGAGGAGAGGAGAAGGGUUUAAGCCGAAGCUGCA… 5773 nt 0.5967
Summary

Enables guanyl-nucleotide exchange factor activity and protein domain specific binding activity. Involved in several processes, including Rap protein signal transduction; cellular response to cAMP; and regulation of syncytium formation by plasma membrane fusion. Located in several cellular components, including filopodium; lamellipodium; and microvillus. Implicated in nicotine dependence. Biomarker of congestive heart failure. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in mice demonstrated that binge-like ethanol consumption via a drinking-in-the-dark paradigm increased the RAPGEF3 expression in the prefrontal cortex, and pharmacological inhibition of PARP with ABT-888 altered its expression as part of a broader transcriptional response [Vallerini et al. DOI:10.1016/J.Neuroscience.2020.09.010].