Basic Information

Symbol
RAPGEF5
RNA class
mRNA
Alias
Rap Guanine Nucleotide Exchange Factor 5 MR-GEF GFR KIAA0277 Rap Guanine Nucleotide Exchange Factor (GEF) 5 Guanine Nucleotide Exchange Factor For Rap1 M-Ras-Regulated Rap GEF M-Ras-Regulated GEF Related To Epac MRGEF REPAC Repac
Location (GRCh38)
7:22118236-22357154
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_012294.5
Sequence length
6916.0 nt
GC content
0.4453

Transcripts

ID Sequence Length GC content
NM_001367600.2 NCBI
AGAUGGACUCAGUUCCCAGUGAAAGGACAGGGAUGGCAAGAUCUUUUAG… 5997 nt 0.4297
NM_001367601.1 NCBI
AGAUGGACUCAGUUCCCAGUGAAAGGACAGGGAUGGCAAGAUCUUUUAG… 1827 nt 0.4444
NM_001367602.2 NCBI
ACACUCACUCUGGGCUGUGGAAGCUGUGUGUGCAGAAAUGAAUCUGUGU… 6181 nt 0.4276
NM_001367603.1 NCBI
AGAUGGACUCAGUUCCCAGUGAAAGGACAGGGAUGGCAAGAUCUUUUAG… 1663 nt 0.4360
NM_012294.5 NCBI
AGUCGCGCCCUCUCGCUUCCUGGCGAAGGCGCGGACGGCGCGCGGAGGC… 6916 nt 0.4453
Summary

Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly dysregulated the RAPGEF5 in cortical glial cells, with the RAPGEF5 being significantly downregulated in microglia as part of the Rap1 signaling pathway [Oladapo et al. DOI:10.3390/Ijms26020649].