Basic Information

Symbol
RAPGEF6
RNA class
mRNA
Alias
Rap Guanine Nucleotide Exchange Factor 6 RA-GEF-2 PDZ-GEF2 PDZGEF2 PDZ Domain Containing Guanine Nucleotide Exchange Factor (GEF) 2 PDZ Domain-Containing Guanine Nucleotide Exchange Factor 2 Rap Guanine Nucleotide Exchange Factor (GEF) 6 PDZ Domain-Containing Guanine Nucleotide Exchange Factor I KIA001LB RAGEF2
Location (GRCh38)
5:131423921-131635234
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_016340.6
Sequence length
8350.0 nt
GC content
0.3990

Transcripts

ID Sequence Length GC content
NM_001164386.2 NCBI
AGACUUGUCUCCGGCCAGUCGCGCGUGGGUAGAGGCCUUAGGCGGGCGU… 8374 nt 0.3997
NM_001164387.2 NCBI
AGACUUGUCUCCGGCCAGUCGCGCGUGGGUAGAGGCCUUAGGCGGGCGU… 8074 nt 0.3958
NM_001164388.2 NCBI
AGACUUGUCUCCGGCCAGUCGCGCGUGGGUAGAGGCCUUAGGCGGGCGU… 8059 nt 0.3961
NM_001164389.2 NCBI
AGACUUGUCUCCGGCCAGUCGCGCGUGGGUAGAGGCCUUAGGCGGGCGU… 4565 nt 0.4145
NM_001164390.2 NCBI
AGACUUGUCUCCGGCCAGUCGCGCGUGGGUAGAGGCCUUAGGCGGGCGU… 3107 nt 0.4059
NM_016340.6 NCBI
AGACUUGUCUCCGGCCAGUCGCGCGUGGGUAGAGGCCUUAGGCGGGCGU… 8350 nt 0.3990
Summary

Enables several functions, including GTP-dependent protein binding activity; guanyl-nucleotide exchange factor activity; and phosphatidic acid binding activity. Involved in microvillus assembly; positive regulation of GTPase activity; and protein localization to plasma membrane. Located in several cellular components, including apical plasma membrane; centrosome; and endocytic vesicle. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

No relevant information is available at the moment.