Basic Information

Symbol
RARRES1
RNA class
mRNA
Alias
Retinoic Acid Receptor Responder 1 TIG1 LXNL Retinoic Acid Receptor Responder (Tazarotene Induced) 1 Retinoic Acid Receptor Responder Protein 1 Phorbol Ester-Induced Gene 1 Protein Tazarotene-Induced Gene 1 Protein RAR-Responsive Protein TIG1 Latexin-Like PERG-1 PEIG1
Location (GRCh38)
3:158696892-158732798
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_206963.2
Sequence length
1713.0 nt
GC content
0.4273

Transcripts

ID Sequence Length GC content
NM_002888.4 NCBI
GAGCCCGUGUCUGUCGGGUGCCGAGCCAACUUUCCUGCGUCCAUGCAGC… 854 nt 0.5410
NM_206963.2 NCBI
GAGCCCGUGUCUGUCGGGUGCCGAGCCAACUUUCCUGCGUCCAUGCAGC… 1713 nt 0.4273
Summary

This gene was identified as a retinoid acid (RA) receptor-responsive gene. It encodes a type 1 membrane protein. The expression of this gene is upregulated by tazarotene as well as by retinoic acid receptors. The expression of this gene is found to be downregulated in prostate cancer, which is caused by the methylation of its promoter and CpG island. Alternatively spliced transcript variant encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Forensic Context

A study in mice demonstrated that the RARRES1 gene, identified as one of 17 feature genes of a specific FGF7+MGST1+ fibroblast subset, was significantly down-regulated in myocardial infarction cardiac tissues compared to other cardiac areas [Wang et al. DOI:10.1016/j.ijbiomac.2025.143171].