Basic Information

Symbol
RASA3
RNA class
mRNA
Alias
RAS P21 Protein Activator 3 GAP1IP4BP GAPIII Ras GTPase-Activating Protein 3 Ins P4-Binding Protein GTPase-Activating Protein 1 Family, Inositol 1,3,4,5-Tetrakisphosphate-Binding Protein Ins(1,3,4,5)P4-Binding Protein GTPase Activating Protein III GAP1(IP4BP)
Location (GRCh38)
13:113977783-114132775
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_007368.4
Sequence length
4203.0 nt
GC content
0.5534

Transcripts

ID Sequence Length GC content
NM_001320821.2 NCBI
AACUGGCGGUCUUGCAGGCGGGCGGACCCUCGGCCGCGCUCGGGGCUCC… 4669 nt 0.5596
NM_001320822.2 NCBI
AGUGCCUUGGAGGUGAUGGCAUCAGAAGCCUGAGGCAGGGAAAUGGGCU… 4167 nt 0.5402
NM_007368.4 NCBI
AACUGGCGGUCUUGCAGGCGGGCGGACCCUCGGCCGCGCUCGGGGCUCC… 4203 nt 0.5534
Summary

This gene encodes a protein that binds inositol 1,3,4,5-tetrakisphosphate and stimulates the GTPase activity of Ras p21. This protein functions as a negative regulator of the Ras signalling pathway. It is localized to the cell membrane via a pleckstrin homology (PH) domain in the C-terminal region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly downregulated the RASA3 in microglia, implicating it within the dysregulated Ras signaling pathway associated with methamphetamine-induced glial dysfunction [Oladapo et al. DOI:10.3390/Ijms26020649].