Basic Information

Symbol
RASD2
RNA class
mRNA
Alias
RASD Family Member 2 TEM2 Ras Homolog Enriched In Striatum Tumor Endothelial Marker 2 Rhes GTP-Binding Protein Rhes MGC:4834 RASD Family, Member 2
Location (GRCh38)
22:35539796-35554003
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_014310.4
Sequence length
3447.0 nt
GC content
0.6098

Transcripts

ID Sequence Length GC content
NM_001366725.1 NCBI
AGACGCUGGCGCUGGGCGGCGGGAGGCGCGGCUCGCGGGGGGCCGAAGG… 2831 nt 0.5821
NM_001376515.1 NCBI
GGUCGUGCUAAUUCCCAGGUUCUUCGGUGCCCUCCAGUUAAAGGGACCC… 3399 nt 0.5616
NM_001376516.1 NCBI
AGGAGACGCAAUGCUCAAGGCACCUGGUGUGUCCCCGUCGGCCGUGGUC… 2870 nt 0.5784
NM_014310.4 NCBI
AGAGCGCCCUGCUCCUCCUUCAGCUGCUGGCGUCGCCGCGCGGGGAGAA… 3447 nt 0.6098
Summary

This gene belongs to the Ras superfamily of small GTPases and is enriched in the striatum. The encoded protein functions as an E3 ligase for attachment of small ubiquitin-like modifier (SUMO). This protein also binds to mutant huntingtin (mHtt), the protein mutated in Huntington disease (HD). Sumoylation of mHTT by this protein may cause degeneration of the striatum. The protein functions as an activator of mechanistic target of rapamycin 1 (mTOR1), which in turn plays a role in myelination, axon growth and regeneration. Reduced levels of mRNA expressed by this gene were found in HD patients. [provided by RefSeq, Jan 2016]

Forensic Context

No relevant information is available at the moment.