Basic Information

Symbol
RASGRF1
RNA class
mRNA
Alias
Ras Protein Specific Guanine Nucleotide Releasing Factor 1 CDC25 GNRP H-GRF55 PP13187 CDC25L GRF55 GRF1 Ras-Specific Guanine Nucleotide-Releasing Factor 1 Ras-Specific Nucleotide Exchange Factor CDC25 Guanine Nucleotide-Releasing Protein Ras-GRF1 Ras-Specific Guanine Nucleotide-Releasing Factor, CDC25 Homolog Guanine Nucleotide-Releasing Factor, 55 KD Guanine Nucleotide-Releasing Factor 1 Guanine Nucleotide Exchange Factor CDC25 Like (S. Cerevisiae) CDC25 Like
Location (GRCh38)
15:78959906-79090780
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001145648.3
Sequence length
6294.0 nt
GC content
0.5261

Transcripts

ID Sequence Length GC content
NM_001145648.3 NCBI
AGUCCCUCAGUUUGCCCGGCACCGGAGGAGGGUCGGGCGGCAUCUUCCG… 6294 nt 0.5261
NM_002891.6 NCBI
AGUCCCUCAGUUUGCCCGGCACCGGAGGAGGGUCGGGCGGCAUCUUCCG… 6342 nt 0.5268
NM_153815.3 NCBI
GGAGCCCUUUUUGGCCUACUUGGGGUGAGUCAACAUAAGGAGUGCAGGC… 4886 nt 0.5074
Summary

The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009]

Forensic Context

A review of transgenerational epigenetic inheritance in mammals noted that the imprinted gene RAS-protein-specific guanine nucleotide-releasing factor 1 (Rasgrf1) in mice serves as a model for piRNA-directed imprinting, where piRNAs target a retrotransposon within a non-coding RNA at its differentially methylated region to establish DNA methylation specifically in the paternal germline [Daxinger & Whitelaw DOI:10.1038/nrg3188].