Basic Information

Symbol
RASGRF2
RNA class
mRNA
Alias
Ras Protein Specific Guanine Nucleotide Releasing Factor 2 Ras-GRF2 GRF2 Ras-Specific Guanine Nucleotide-Releasing Factor 2 Ras Guanine Nucleotide Exchange Factor 2
Location (GRCh38)
5:80960310-81230162
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_006909.3
Sequence length
8482.0 nt
GC content
0.4583

Transcripts

ID Sequence Length GC content
NM_006909.3 NCBI
AGUCCUUCCCCGGCUGCCGCCCCAGCCCGCCGCGGGGGCUCGGCUCCCG… 8482 nt 0.4583
Summary

RAS GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. This gene encodes a calcium-regulated nucleotide exchange factor activating both RAS and RAS-related protein, RAC1, through the exchange of bound GDP for GTP, thereby, coordinating the signaling of distinct mitogen-activated protein kinase pathways. [provided by RefSeq, Oct 2011]

Forensic Context

A study in human forensic autopsy cases using RNA sequencing demonstrated that the RASGRF2 was upregulated in a case of fatal insulin overdose, indicating its role as an additional adaptor/signaling molecule within the insulin signaling pathway [Nakao et al. DOI:10.1016/j.legalmed.2025.102772].