Basic Information

Symbol
RASGRP1
RNA class
mRNA
Alias
RAS Guanyl Releasing Protein 1 CalDAG-GEFII RASGRP Calcium- And Diacylglycerol-Regulated Guanine Nucleotide Exchange Factor II Calcium And DAG-Regulated Guanine Nucleotide Exchange Factor II RAS Guanyl Releasing Protein 1 (Calcium And DAG-Regulated) RAS Guanyl-Releasing Protein 1 Guanine Nucleotide Exchange Factor, Calcium- And DAG-Regulated, Rap1A RAS Guanyl Nucleotide-Releasing Protein 1 Ras Guanyl-Releasing Protein Ras Activator RasGRP CALDAG-GEFI IMD64
Location (GRCh38)
15:38488103-38565575
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Time since deposition estimation Postmortem interval inference
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_005739.4
Sequence length
5031.0 nt
GC content
0.4274

Transcripts

ID Sequence Length GC content
NM_001128602.2 NCBI
GCGCUCGCACAAAGUUUGUGCCUGCGGUGCACCUCGGUCGGGCUCGCCG… 4926 nt 0.4259
NM_001306086.2 NCBI
GCGCUCGCACAAAGUUUGUGCCUGCGGUGCACCUCGGUCGGGCUCGCCG… 4540 nt 0.4174
NM_005739.4 NCBI
GCGCUCGCACAAAGUUUGUGCCUGCGGUGCACCUCGGUCGGGCUCGCCG… 5031 nt 0.4274
Summary

This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]

Forensic Context

A study in humans identified RASGRP1 as a lysosome-related gene whose expression in peripheral blood was significantly higher in normal controls compared to sepsis patients, with high expression correlating with a higher 28-day survival rate in sepsis patients [Chen et al. DOI:10.1186/s12865-023-00588-7]. A study in zebrafish demonstrated that the RASGRP1 transcript, a cancer-associated signalling protein, increased in abundance postmortem [Pozhitkov et al. DOI:10.1098/rsob.160267].