Basic Information

Symbol
RASGRP2
RNA class
mRNA
Alias
RAS Guanyl Releasing Protein 2 CALDAG-GEFI Calcium And DAG-Regulated Guanine Nucleotide Exchange Factor I RAS Guanyl Releasing Protein 2 (Calcium And DAG-Regulated) RAS Guanyl-Releasing Protein 2 F25B3.3 Kinase-Like Protein Cdc25-Like Protein CDC25L Calcium- And Diacylglycerol-Regulated Guanine Nucleotide Exchange Factor I Calcium And Diacylglycerol-Regulated Guanine Nucleotide Exchange Factor I RAS Guanyl Nucleotide-Releasing Protein 2 Guanine Exchange Factor MCG7 CalDAG-GEFI HCDC25L MCG7
Location (GRCh38)
11:64726905-64745456
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001098671.2
Sequence length
2268.0 nt
GC content
0.6085

Transcripts

ID Sequence Length GC content
NM_001098670.2 NCBI
GCAGCCGCAGCGAGGCCGGCGGGCGGGAGCGCACGGAGGUGGGGUCGGC… 2213 nt 0.6132
NM_001098671.2 NCBI
ACUGCCUUGCGUGUGUGCACACGUGUGAGGAUGUCAGCGCCUGUGUGGC… 2268 nt 0.6085
NM_001318398.2 NCBI
ACUGCCUUGCGUGUGUGCACACGUGUGAGGAUGUCAGCGCCUGUGUGGC… 2188 nt 0.6079
NM_153819.1 NCBI
CGAUUUCAUUCCUCGCUCCCCACAGGUCCCUCUCCCCAAAAUAUUCCCA… 2310 nt 0.6087
Summary

The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Four alternatively spliced transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

Forensic Context

A study in mice demonstrated that binge-like ethanol consumption via a drinking-in-the-dark paradigm altered the expression of the RASGRP2 in the prefrontal cortex, as identified through RNA-seq analysis [Vallerini et al. DOI:10.1016/J.Neuroscience.2020.09.010].