Basic Information

Symbol
RASSF6
RNA class
mRNA
Alias
Ras Association Domain Family Member 6 Ras Association (RalGDS/AF-6) Domain Family Member 6 Ras Association Domain-Containing Protein 6 Ras Association (RalGDS/AF-6) Domain Family 6 Putative RAS Binding Protein
Location (GRCh38)
4:73571550-73620631
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Postmortem interval inference
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_177532.5
Sequence length
5882.0 nt
GC content
0.3677

Transcripts

ID Sequence Length GC content
NM_001270391.2 NCBI
GAGUGACUCGCGGAGUCCCAGCCCGGCAGAGACAGGGCACUGGUUUCCC… 5780 nt 0.3685
NM_001270392.1 NCBI
ACUGAGGCACAGGGAGUGGCUCAGGUUUCUUGACACUUCCCUGCUGUGG… 5818 nt 0.3718
NM_177532.5 NCBI
GAGUGACUCGCGGAGUCCCAGCCCGGCAGAGACAGGGCACUGGUUUCCC… 5882 nt 0.3677
NM_201431.2 NCBI
ACUGAGGCACAGGGAGUGGCUCAGGUUUCUUGACACUUCCCUGCUGUGG… 5950 nt 0.3703
Summary

This gene encodes a member of the Ras-association domain family (RASSF). Members of this family form the core of a highly conserved tumor suppressor network, the Salvador-Warts-Hippo (SWH) pathway. The protein encoded by this gene is a Ras effector protein that induces apoptosis. A genomic region containing this gene has been linked to susceptibility to viral bronchiolitis. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]

Forensic Context

A study in zebrafish and mouse demonstrated that the RASSF6 transcript, a pro-apoptotic and cancer-associated protein, increased in relative abundance at 24 hours postmortem in zebrafish. The research identified 1063 genes with significantly increased transcript levels after death, with functional categorization revealing involvement in apoptosis, among other pathways, suggesting a step-wise shutdown during organismal death [Pozhitkov et al. DOI:10.1098/rsob.160267].