Basic Information

Symbol
RB1CC1
RNA class
mRNA
Alias
RB1 Inducible Coiled-Coil 1 FIP200 KIAA0203 PPP1R131 ATG17 Cc1 FAK Family Kinase-Interacting Protein Of 200 KDa 200 KDa FAK Family Kinase-Interacting Protein Phosphatase 1, Regulatory Subunit 131 RB1-Inducible Coiled-Coil Protein 1 DRAGOU14 RBICC
Location (GRCh38)
8:52622458-52745843
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_014781.5
Sequence length
6636.0 nt
GC content
0.3757

Transcripts

ID Sequence Length GC content
NM_001083617.2 NCBI
GGAGUCGACAAUAACAAACCAAGCCGCGGCGGUGUCCGCGGCCCUGCCG… 6627 nt 0.3753
NM_014781.5 NCBI
GGAGUCGACAAUAACAAACCAAGCCGCGGCGGUGUCCGCGGCCCUGCCG… 6636 nt 0.3757
Summary

The protein encoded by this gene interacts with signaling pathways to coordinately regulate cell growth, cell proliferation, apoptosis, autophagy, and cell migration. This tumor suppressor also enhances retinoblastoma 1 gene expression in cancer cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2009]

Forensic Context

A study in mice demonstrated that the RB1CC1 was significantly dysregulated in microglia after chronic methamphetamine administration, where it was identified as a key gene in the autophagy pathway [Oladapo et al. DOI:10.3390/Ijms26020649]. In a separate investigation of nicotine self-administration in mice, the RB1CC1 was identified as a hub gene related to synaptic plasticity during the post-addiction phase in the ventral tegmental area [Fan et al. DOI:10.1016/J.Jgg.2024.08.009].