Basic Information

Symbol
RBBP7
RNA class
mRNA
Alias
RB Binding Protein 7, Chromatin Remodeling Factor Histone Acetyltransferase Type B Subunit 2 Retinoblastoma-Binding Protein P46 Retinoblastoma-Binding Protein 7 RbAp46 G1/S Transition Control Protein-Binding Protein RbAp46 Nucleosome-Remodeling Factor Subunit RBAP46 Retinoblastoma-Binding Protein RbAp46 Histone-Binding Protein RBBP7 RBBP-7 Retinoblastoma Binding Protein 7 RB Binding Protein 7 SPGFX9 RBAP46
Location (GRCh38)
X:16839283-16870372
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002893.4
Sequence length
2281.0 nt
GC content
0.4450

Transcripts

ID Sequence Length GC content
NM_001198719.2 NCBI
GGGCUCCGAGCACUUCCGGAGCCGGGCGCGGGGCCGAGGGCUGGGCCCC… 2326 nt 0.4596
NM_002893.4 NCBI
ACUUUUCCCAGGGCGGAUGCGCCUGCGCUCAGCUGCCUGGGCGGGCUGG… 2281 nt 0.4450
Summary

This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

Forensic Context

A study in human dermal lymphatic endothelial cells (LECs) demonstrated that the lncRNA LETR1 is a nuclear trans-acting regulator of LEC proliferation and migration, functioning by interacting with the histone-binding protein RBBP7 [Ducoli et al. DOI:10.1038/s41467-021-21217-0]. This interaction was shown to mediate the recruitment of RNA polymerase II to the promoters of key target genes, including KLF4 and SEMA3C, thereby governing the global LEC transcriptome and cellular phenotypes.