Basic Information

Symbol
RBFOX3
RNA class
mRNA
Alias
RNA Binding Fox-1 Homolog 3 HRNBP3 FOX-3 NeuN Hexaribonucleotide Binding Protein 3 RNA Binding Protein, Fox-1 Homolog 3 RNA Binding Protein Fox-1 Homolog 3 Neuronal Nuclei Antigen Fox-1 Homolog C NeuN Antigen RNA Binding Protein, Fox-1 Homolog (C. Elegans) 3 Neuronal Nuclei FOX3
Location (GRCh38)
17:79089345-79611258
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001350451.2
Sequence length
3163.0 nt
GC content
0.6244

Transcripts

ID Sequence Length GC content
NM_001082575.3 NCBI
AGGCUGUGCGUGCUCUCUCUGCCUCUCUCUCUCGGACUCUCUGCUCUCU… 2962 nt 0.6080
NM_001350451.2 NCBI
AGCAGAACCUCCUCGGACAGCGGCCCCAGCCGGGCCCCAGCAGCUCGCG… 3163 nt 0.6244
NM_001350453.2 NCBI
AGCAGAACCUCCUCGGACAGCGGCCCCAGCCGGGCCCCAGCAGCUCGCG… 2982 nt 0.6258
NM_001385804.1 NCBI
AGCAGAACCUCCUCGGACAGCGGCCCCAGCCGGGCCCCAGCAGCUCGCG… 2317 nt 0.6215
NM_001385805.1 NCBI
AAACCUUUCCGCAAACCUAUGAGAUGUGAGUGUGUUUUCUACUGCAGCA… 2337 nt 0.5858
NM_001385806.1 NCBI
AGCAGAACCUCCUCGGACAGCGGCCCCAGCCGGGCCCCAGCAGCUCGCG… 2314 nt 0.6214
NM_001385807.1 NCBI
AAACCUUUCCGCAAACCUAUGAGAUGUGAGUGUGUUUUCUACUGCAGCA… 3408 nt 0.5869
NM_001385808.1 NCBI
GGAGAGUCCUUGAGUCCAUGGAAGCACAGGGCAAGGCCCUGGGCUCCUG… 3332 nt 0.6125
NM_001385809.1 NCBI
AUUAAGUGUGCAUCGCGGAUUCGGGACGGAUGUCUUAAUUAGGCUGCGU… 3232 nt 0.6071
NM_001385810.1 NCBI
GGCUGUUGGCAGAGUUGCGUGAGGCCAUUCACGCCGCCACUUGAGGACC… 2990 nt 0.6120
Showing 1 to 10 of 47 entries
Summary

This gene encodes a member of the RNA-binding FOX protein family which is involved in the regulation of alternative splicing of pre-mRNA. The protein has an N-terminal proline-rich region, an RNA recognition motif (RRM) domain, and a C-terminal alanine-rich region. This gene produces the neuronal nuclei (NeuN) antigen that has been widely used as a marker for post-mitotic neurons. This gene has its highest expression in the central nervous system and plays a prominent role in neural tissue development and regulation of adult brain function. Mutations in this gene have been associated with numerous neurological disorders. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2017]

Forensic Context

A study in rats demonstrated that traumatic brain injury (TBI) induced by lateral fluid percussion caused significant neuronal loss in the impacted cerebral cortex by 48 hours post-injury, as evidenced by decreased NeuN-positive neuron counts and shrunken neuronal morphology [Shojo et al. DOI:10.1016/j.neuroscience.2010.10.018]. This histopathological marker of neuronal integrity showed a temporal progression alongside other apoptotic and inflammatory markers, supporting its role in characterizing the extent of TBI-related neurodegeneration within the examined subacute phase. A study in mice demonstrated that the RBFOX3 mRNA was low or absent in magnetically isolated CD31+ endothelial cell fractions, confirming successful enrichment of endothelial cells for subsequent analysis of age-dependent vascular responses to traumatic brain injury [Brickler et al. DOI:10.1523/JNEUROSCI.0914-18.2018].