Basic Information

Symbol
RBFOX3
RNA class
mRNA
Alias
RNA Binding Fox-1 Homolog 3 HRNBP3 FOX-3 NeuN Hexaribonucleotide Binding Protein 3 RNA Binding Protein, Fox-1 Homolog 3 RNA Binding Protein Fox-1 Homolog 3 Neuronal Nuclei Antigen Fox-1 Homolog C NeuN Antigen RNA Binding Protein, Fox-1 Homolog (C. Elegans) 3 Neuronal Nuclei FOX3
Location (GRCh38)
17:79089345-79611258
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001350451.2
Sequence length
3163.0 nt
GC content
0.6244

Transcripts

ID Sequence Length GC content
NM_001385811.1 NCBI
UGGCAGCUGGAGCUCCGGCCCGGCCCGAGGGGGAAGACUAUGGCUGUUG… 3834 nt 0.6179
NM_001385812.1 NCBI
UGGCAGCUGGAGCUCCGGCCCGGCCCGAGGGGGAAGACUAUGGCUGUUG… 3794 nt 0.6191
NM_001385813.1 NCBI
AGCAGAACCUCCUCGGACAGCGGCCCCAGCCGGGCCCCAGCAGCUCGCG… 3352 nt 0.6247
NM_001385814.1 NCBI
AGCAGAACCUCCUCGGACAGCGGCCCCAGCCGGGCCCCAGCAGCUCGCG… 3123 nt 0.6260
NM_001385815.1 NCBI
AGCAGAACCUCCUCGGACAGCGGCCCCAGCCGGGCCCCAGCAGCUCGCG… 3295 nt 0.6231
NM_001385816.1 NCBI
AGCAGAACCUCCUCGGACAGCGGCCCCAGCCGGGCCCCAGCAGCUCGCG… 3432 nt 0.6200
NM_001385817.1 NCBI
GUAAGCCUUCCUGUGGGCGGCCUGGGCAGAGCUACCUCCAUCAACCCUG… 3160 nt 0.6089
NM_001385818.1 NCBI
AGCAGAACCUCCUCGGACAGCGGCCCCAGCCGGGCCCCAGCAGCUCGCG… 3234 nt 0.6246
NM_001385819.1 NCBI
AGACUAAUUCGGAGUGAAAUGUUUUAGCAAUGGUGGGCUGAUUCUAUCA… 3236 nt 0.5983
NM_001385820.1 NCBI
AGCAGAACCUCCUCGGACAGCGGCCCCAGCCGGGCCCCAGCAGCUCGCG… 3298 nt 0.6198
Showing 11 to 20 of 47 entries
Summary

This gene encodes a member of the RNA-binding FOX protein family which is involved in the regulation of alternative splicing of pre-mRNA. The protein has an N-terminal proline-rich region, an RNA recognition motif (RRM) domain, and a C-terminal alanine-rich region. This gene produces the neuronal nuclei (NeuN) antigen that has been widely used as a marker for post-mitotic neurons. This gene has its highest expression in the central nervous system and plays a prominent role in neural tissue development and regulation of adult brain function. Mutations in this gene have been associated with numerous neurological disorders. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2017]

Forensic Context

A study in rats demonstrated that traumatic brain injury (TBI) induced by lateral fluid percussion caused significant neuronal loss in the impacted cerebral cortex by 48 hours post-injury, as evidenced by decreased NeuN-positive neuron counts and shrunken neuronal morphology [Shojo et al. DOI:10.1016/j.neuroscience.2010.10.018]. This histopathological marker of neuronal integrity showed a temporal progression alongside other apoptotic and inflammatory markers, supporting its role in characterizing the extent of TBI-related neurodegeneration within the examined subacute phase. A study in mice demonstrated that the RBFOX3 mRNA was low or absent in magnetically isolated CD31+ endothelial cell fractions, confirming successful enrichment of endothelial cells for subsequent analysis of age-dependent vascular responses to traumatic brain injury [Brickler et al. DOI:10.1523/JNEUROSCI.0914-18.2018].