Basic Information

Symbol
RBFOX3
RNA class
mRNA
Alias
RNA Binding Fox-1 Homolog 3 HRNBP3 FOX-3 NeuN Hexaribonucleotide Binding Protein 3 RNA Binding Protein, Fox-1 Homolog 3 RNA Binding Protein Fox-1 Homolog 3 Neuronal Nuclei Antigen Fox-1 Homolog C NeuN Antigen RNA Binding Protein, Fox-1 Homolog (C. Elegans) 3 Neuronal Nuclei FOX3
Location (GRCh38)
17:79089345-79611258
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001350451.2
Sequence length
3163.0 nt
GC content
0.6244

Transcripts

ID Sequence Length GC content
NM_001385831.1 NCBI
GAGACAGCCUGGGCCUGGCGAGGUGGCUGCGUGCGUGCGGCAGGGGUUG… 2892 nt 0.6138
NM_001385832.1 NCBI
GGAGAGUCCUUGAGUCCAUGGAAGCACAGGGCAAGGCCCUGGGCUCCUG… 3287 nt 0.6145
NM_001385833.1 NCBI
CUGCUGUGUGCGGAGCGGGUGGUCAGCGGCCUGGCGGUCAGCUGUGAGG… 2863 nt 0.6123
NM_001385834.1 NCBI
GGAGAGUCCUUGAGUCCAUGGAAGCACAGGGCAAGGCCCUGGGCUCCUG… 3681 nt 0.6039
NM_001385835.1 NCBI
GGCUGUUGGCAGAGUUGCGUGAGGCCAUUCACGCCGCCACUUGAGGACC… 2849 nt 0.6111
NM_001385836.1 NCBI
CGUGCACCCUUCCCAGCCUUGCCACCCAGGGCAGGCUCUGGAACCUCAG… 2910 nt 0.6103
NM_001385837.1 NCBI
UGGCAGCUGGAGCUCCGGCCCGGCCCGAGGGGGAAGACUAUGGCUGUUG… 3693 nt 0.6174
NM_001385838.1 NCBI
GAGAUGUGAGUGUGUUUUCUACUGCAGCAGAACCUACACUAUCCCAGUG… 2883 nt 0.6063
NM_001385839.1 NCBI
AGCAGAACCUCCUCGGACAGCGGCCCCAGCCGGGCCCCAGCAGCUCGCG… 3211 nt 0.6244
NM_001385840.1 NCBI
AUUAAGUGUGCAUCGCGGAUUCGGGACGGAUGUCUUAAUUAGGCUGCGU… 2887 nt 0.6062
Showing 31 to 40 of 47 entries
Summary

This gene encodes a member of the RNA-binding FOX protein family which is involved in the regulation of alternative splicing of pre-mRNA. The protein has an N-terminal proline-rich region, an RNA recognition motif (RRM) domain, and a C-terminal alanine-rich region. This gene produces the neuronal nuclei (NeuN) antigen that has been widely used as a marker for post-mitotic neurons. This gene has its highest expression in the central nervous system and plays a prominent role in neural tissue development and regulation of adult brain function. Mutations in this gene have been associated with numerous neurological disorders. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2017]

Forensic Context

A study in rats demonstrated that traumatic brain injury (TBI) induced by lateral fluid percussion caused significant neuronal loss in the impacted cerebral cortex by 48 hours post-injury, as evidenced by decreased NeuN-positive neuron counts and shrunken neuronal morphology [Shojo et al. DOI:10.1016/j.neuroscience.2010.10.018]. This histopathological marker of neuronal integrity showed a temporal progression alongside other apoptotic and inflammatory markers, supporting its role in characterizing the extent of TBI-related neurodegeneration within the examined subacute phase. A study in mice demonstrated that the RBFOX3 mRNA was low or absent in magnetically isolated CD31+ endothelial cell fractions, confirming successful enrichment of endothelial cells for subsequent analysis of age-dependent vascular responses to traumatic brain injury [Brickler et al. DOI:10.1523/JNEUROSCI.0914-18.2018].