Basic Information

Symbol
RBL2
RNA class
mRNA
Alias
RB Transcriptional Corepressor Like 2 P130 Rb2 130 KDa Retinoblastoma-Associated Protein Retinoblastoma-Related Protein 2 Retinoblastoma-Like Protein 2 Retinoblastoma-Like 2 RBR-2 BRUWAG PRB2 PRb2 RB2
Location (GRCh38)
16:53433977-53491649
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_005611.4
Sequence length
4854.0 nt
GC content
0.4277

Transcripts

ID Sequence Length GC content
NM_001323608.2 NCBI
GGCGGACGGGCGGGCGCUUCGCCGUUUGAAUGGCUGCGGGCCCGGGCCC… 4641 nt 0.4299
NM_001323609.2 NCBI
GGCGGACGGGCGGGCGCUUCGCCGUUUGAAUGGCUGCGGGCCCGGGCCC… 4782 nt 0.4266
NM_001323610.2 NCBI
GGCGGACGGGCGGGCGCUUCGCCGUUUGAAUGGCUGCGGGCCCGGGCCC… 4707 nt 0.4260
NM_001323611.1 NCBI
GUUUAUCAGCUGUUUGACUGUGUGUGUGGCAUUUAAACCUGAGGCCAUU… 4654 nt 0.4055
NM_005611.4 NCBI
GGCGGACGGGCGGGCGCUUCGCCGUUUGAAUGGCUGCGGGCCCGGGCCC… 4854 nt 0.4277
Summary

Enables promoter-specific chromatin binding activity. Involved in regulation of lipid kinase activity. Acts upstream of or within negative regulation of gene expression. Located in chromosome; cytosol; and nuclear lumen. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in humans demonstrated that RBL2 was identified in 48 out of 50 saliva samples with 46.64% average sequence coverage as part of a validated, protease-free mass spectrometry assay for body fluid identification [Brown et al. DOI:10.1021/acs.jproteome.5c00711]. RBL2 was detected in 48 out of 50 saliva samples with 46.64% average sequence coverage and was successfully validated in sensitivity dilutions, aged samples, and on various substrates, confirming its forensic utility for body fluid identification in sexual assault evidence.